Evidence map›Paper›PMID 27001684›Full record

ReviewLangenbeck's archives of surgery2016

Ruptured abdominal aortic aneurysm-epidemiology, predisposing factors, and biology.

Thomas Schmitz-Rixen, M Keese, M Hakimi, A Peters, D Böckler, K Nelson, R T Grundmann

Abstract readReview
PubMed Publisher
In one paragraph

Review in Langenbeck's archives of surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Circ-LRP6 Inhibits the Development and Progression of AAACurrent pharmaceutical biotechnology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. A Social Network Analysis Approach to COVID-19 Community Detection Techniques.International journal of environmental research and public health · 2022
    Article
  20. Beliefs about Pain Control in Patients after Abdominal Aortic Aneurysm Surgery-A Preliminary Study.International journal of environmental research and public health · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Thomas Schmitz-RixenKlinik für Gefäß- und Endovascularchirurgie, Klinikum der Goethe-Universität, Frankfurt am Main, Germany. schmitz-rixen@em.uni-frankfurt.de.
M KeeseKlinik für Gefäß- und Endovascularchirurgie, Klinikum der Goethe-Universität, Frankfurt am Main, Germany.
M HakimiKlinik für Gefäßchirurgie und Endovaskuläre Chirurgie, Universitätsklinikum Heidelberg, Heidelberg, Germany.
A PetersKlinik für Gefäßchirurgie und Endovaskuläre Chirurgie, Universitätsklinikum Heidelberg, Heidelberg, Germany.
D BöcklerKlinik für Gefäßchirurgie und Endovaskuläre Chirurgie, Universitätsklinikum Heidelberg, Heidelberg, Germany.
K NelsonKlinik für Gefäß- und Endovascularchirurgie, Klinikum der Goethe-Universität, Frankfurt am Main, Germany.
R T GrundmannDeutsches Institut für Gefäßmedizinische Gesundheitsforschung gGmbH (DIGG) der DGG, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAbdominal aortic aneurysm is a common degenerative vascular disorder associated with sudden death due to aortic rupture. This review describes epidemiology, predisposing factors, and biology of ruptured abdominal aortic aneurysms (rAAAs).

methodsBased on a selective literature search in Medline (PubMed), original publications, meta-analyses, systematic reviews, and Cochrane reviews were evaluated for rAAA.

resultsThe hospital admission rate for rAAA is decreasing and is now in the range of approximately 10 per 100,000 population in men. Smoking contributes to about 50 % of population risk for rupture or surgically treated AAA. AAA rupture is a multifaceted biological process involving biochemical, cellular, and proteolytic influences, in addition to biomechanical factors. AAA rupture occurs when the stress (force per unit area) on the aneurysm wall exceeds wall strength. Proteolytic activities of matrix metalloproteinases have been implicated in aneurysm wall weakening and rupture. Aneurysm diameter is the most prominent predisposing factor for aneurysm growth and rupture. Wall stress, aneurysm shape and geometry, intraluminal thrombus, wall thickness, calcification, and metabolic activity influence the rupture risk.

conclusionThe best conservative option to avoid AAA rupture consists in smoking cessation and control of hypertension. Many biological factors influence rupture risk.

Indexed as

Aortic Aneurysm, AbdominalAortic RuptureHumansRisk Factors18F-FDG uptakeDiameterEpidemiologyPeak wall stressRuptured abdominal aortic aneurysmWall thickness

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.