ReviewInternational journal of obesity (2005)2016
Added sugars and risk factors for obesity, diabetes and heart disease.
Review in International journal of obesity (2005), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 57 citations in OpenAlex.
- A pilot feasibility study investigating the impact of increasing sucrose intakes on body composition and blood pressure.Journal of nutritional science · 2021Trial
- The carbon isotope ratio of alanine is a biomarker of added sugar and sugar-sweetened beverage intakes: a pooled analysis of 4 studies.The American journal of clinical nutrition · 2025Article
- Who Likes Sweets? Sweet Patterns: Influence of Sex, Age, Body Mass Index, Smoking and Olfactory Efficiency on the Consumption of Sweet Products.Nutrients · 2025Article
- Exposure to sugar rationing in the first 1000 days of life protected against chronic disease.Science (New York, N.Y.) · 2024Article
- Alteration of oral microbial biofilms by sweeteners.Biofilm · 2024Review
- Sources of free sugar in the diet of Saudi children.Frontiers in public health · 2024Article
- Fructose: a modulator of intestinal barrier function and hepatic health?European journal of nutrition · 2023Review
- Nutritional Value of Meals Designed for a School-Based Food Aid Program and Comparison with Similar Commercial Products: An Example of Good Practice from the DIATROFI Program.Children (Basel, Switzerland) · 2023Article
- Tiered dietary exposure assessment of steviol glycosides in the Belgian population.Journal of nutritional science · 2023Article
- Effects of reducing free sugars on 24-hour glucose profiles and glycemic variability in subjects without diabetes.Frontiers in nutrition · 2023Article
- Long-Term Memory Function Impairments following Sucrose Exposure in Juvenile versus Adult Rats.Biomedicines · 2022Article
- Evaluating a Model of Added Sugar Intake Based on Amino Acid Carbon Isotope Ratios in a Controlled Feeding Study of U.S. Adults.Nutrients · 2022Article
- Prebiotic Potential of a New Sweetener Based on Galactooligosaccharides and Modified Mogrosides.Journal of agricultural and food chemistry · 2022Article
- Associations of Binge Drinking and Heavy Alcohol Use on Sugar and Fat Intake in a Cohort of Southern People Living with HIV.Alcohol and alcoholism (Oxford, Oxfordshire) · 2022Article
- Commercial use of evidence in public health policy: a critical assessment of food industry submissions to global-level consultations on non-communicable disease prevention.BMJ global health · 2021Article
- Body mass index and potential correlates among elementary school children in Jordan.Eating and weight disorders : EWD · 2021Article
- Editorial: What Level of Added or Free Sugar Is Commensurate With Good Health Outcomes?Frontiers in nutrition · 2021Article
- Carbohydrates to Prevent and Treat Obesity in a Murine Model of Diet-Induced Obesity.Obesity facts · 2021Article
- What is the best diet for cardiovascular wellness? A comparison of different nutritional models.International journal of obesity supplements · 2020Review
- High-sugar diet leads to obesity and metabolic diseases in ad libitum -fed rats irrespective of caloric intake.Archives of endocrinology and metabolism · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of added sugars on various chronic conditions are highly controversial. Some investigators have argued that added sugars increase the risk of obesity, diabetes and cardiovascular disease. However, few randomized controlled trials are available to support these assertions. The literature is further complicated by animal studies, as well as studies which compare pure fructose to pure glucose (neither of which is consumed to any appreciable degree in the human diet) and studies where large doses of added sugars beyond normal levels of human consumption have been administered. Various scientific and public health organizations have offered disparate recommendations for upper limits of added sugar. In this article, we will review recent randomized controlled trials and prospective cohort studies. We conclude that the normal added sugars in the human diet (for example, sucrose, high-fructose corn syrup and isoglucose) when consumed within the normal range of normal human consumption or substituted isoenergetically for other carbohydrates, do not appear to cause a unique risk of obesity, diabetes or cardiovascular disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.