Evidence map›Paper›PMID 27001615›Full record

ArticleMolecular psychiatry2016

Therapeutically relevant structural and functional mechanisms triggered by physical and cognitive exercise.

C Suo, M Fiatarone Singh, N Gates, W Wen, P Sachdev, H Brodaty, N Saigal, G C Wilson, J Meiklejohn, N Singh and 8 more

Erratum issued Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06755164 (Effects of Combined Aerobic and Cognitive Training in a Simultaneous or Sequential Paradigm on Cognition and Brain Functional Activity in Patients with Amnesic Mild Cognitive Impairment), which is not on this map. Cited by 97 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06755164 naactive not recruitingnot on this mapstarted 2019, after this paper: background citation

Effects of Combined Aerobic and Cognitive Training in a Simultaneous or Sequential Paradigm on Cognition and Brain Functional Activity in Patients with Amnesic Mild Cognitive Impairment

TypeinterventionalSponsorIRCCS San RaffaeleRan2019 to 2025Enrolled55ConditionsMild Cognitive Impairment (MCI), AMCI - Amnestic Mild Cognitive Impairment, Neurodegenerative Dementia, Neurodegenerative DiseaseArmsSimultaneous aerobic and cognitive training (SIM), Sequential aerobic and cognitive training (SEQ)
3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 12 syntheses or guidelines pooled it.

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  19. Nutritional supplementation boosts aerobic exercise effects on functional brain systems.Journal of applied physiology (Bethesda, Md. : 1985) · 2019
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37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

C SuoRegenerative Neuroscience Group, Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia.
M Fiatarone SinghExercise Health and Performance Faculty Research Group, Faculty of Health Sciences and Sydney Medical School, The University of Sydney, Lidcombe, NSW, Australia.
N GatesRegenerative Neuroscience Group, Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia.
W WenCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.
P SachdevCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.ORCID 0000-0002-9595-3220
H BrodatyCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.
N SaigalExercise Health and Performance Faculty Research Group, Faculty of Health Sciences, The University of Sydney, Lidcombe, NSW, Australia.
G C WilsonExercise Health and Performance Faculty Research Group, Faculty of Health Sciences, The University of Sydney, Lidcombe, NSW, Australia.
J MeiklejohnExercise Health and Performance Faculty Research Group, Faculty of Health Sciences, The University of Sydney, Lidcombe, NSW, Australia.
N SinghExercise Health and Performance Faculty Research Group, Faculty of Health Sciences, The University of Sydney, Lidcombe, NSW, Australia.
B T BauneDepartment of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA, Australia.
M BakerExercise Health and Performance Faculty Research Group, Faculty of Health Sciences and Sydney Medical School, The University of Sydney, Lidcombe, NSW, Australia.
N ForoughiClinical and Rehabilitation Research Group, Faculty of Health Sciences, The University of Sydney, Lidcombe, NSW, Australia.
Y WangExercise Health and Performance Faculty Research Group, Faculty of Health Sciences, The University of Sydney, Lidcombe, NSW, Australia.
Y MavrosExercise Health and Performance Faculty Research Group, Faculty of Health Sciences and Sydney Medical School, The University of Sydney, Lidcombe, NSW, Australia.ORCID 0000-0002-2588-0425
A LampitRegenerative Neuroscience Group, Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia.
I LeungRegenerative Neuroscience Group, Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia.
M J ValenzuelaRegenerative Neuroscience Group, Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Physical and cognitive exercise may prevent or delay dementia in later life but the neural mechanisms underlying these therapeutic benefits are largely unknown. We examined structural and functional magnetic resonance imaging (MRI) brain changes after 6 months of progressive resistance training (PRT), computerized cognitive training (CCT) or combined intervention. A total of 100 older individuals (68 females, average age=70.1, s.d.±6.7, 55-87 years) with dementia prodrome mild cognitive impairment were recruited in the SMART (Study of Mental Activity and Resistance Training) Trial. Participants were randomly assigned into four intervention groups: PRT+CCT, PRT+SHAM CCT, CCT+SHAM PRT and double SHAM. Multimodal MRI was conducted at baseline and at 6 months of follow-up (immediately after training) to measure structural and spontaneous functional changes in the brain, with a focus on the hippocampus and posterior cingulate regions. Participants' cognitive changes were also assessed before and after training. We found that PRT but not CCT significantly improved global cognition (F(90)=4.1, P<0.05) as well as expanded gray matter in the posterior cingulate (P

Indexed as

AgedAged, 80 and overBrainCognitionCognitive DysfunctionExerciseFemaleGray MatterHumansMagnetic Resonance ImagingMaleMemoryMiddle AgedResistance TrainingStructure-Activity Relationship

Identifiers

PMID27001615
PMCPMC5078857

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.