ArticleScientific reports2016
Enrichment of IFN-γ producing cells in different murine adipose tissue depots upon infection with an apicomplexan parasite.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Cytokine production by bovine adipose tissue stromal vascular fraction cells upon Neospora caninum stimulation.Scientific reports · 2024Article
- Protective Immunity AgainstFrontiers in veterinary science · 2021Article
- Modulation of Leptin and Leptin Receptor Expression in Mice Acutely Infected withPathogens (Basel, Switzerland) · 2020Article
- From Signaling Pathways to Distinct Immune Responses: Key Factors for Establishing or CombatingPathogens (Basel, Switzerland) · 2020Review
- Immediate Interferon Gamma Induction Determines Murine Host Compatibility Differences between Toxoplasma gondii and Neospora caninum.Infection and immunity · 2020Article
- Characterization of Myeloid Cellular Populations in Mesenteric and Subcutaneous Adipose Tissue of Holstein-Friesian Cows.Scientific reports · 2020Article
- Obesity Expands a Distinct Population of T Cells in Adipose Tissue and Increases Vulnerability to Infection.Cell reports · 2019Article
- T cells in mesenteric and subcutaneous adipose tissue of Holstein-Friesian cows.Scientific reports · 2019Article
- NLRP3 Inflammasome Participates in Host Response toFrontiers in immunology · 2018Article
- NLRP3 inflammasome activation in murine macrophages caused by Neospora caninum infection.Parasites & vectors · 2017Article
- Dectin-1 Compromises Innate Responses and Host Resistance againstFrontiers in immunology · 2017Article
- Activation of ERK Signaling via TLR11 Induces IL-12p40 Production in Peritoneal Macrophages Challenged byFrontiers in microbiology · 2017Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here we report that lean mice infected with the intracellular parasite Neospora caninum show a fast but sustained increase in the frequency of IFN-γ-producing cells noticeable in distinct adipose tissue depots. Moreover, IFN-γ-mediated immune memory could be evoked in vitro in parasite antigen-stimulated adipose tissue stromal vascular fraction cells collected from mice infected one year before. Innate or innate-like cells such as NK, NK T and TCRγδ(+) cells, but also CD4(+) and CD8(+) TCRβ(+) lymphocytes contributed to the IFN-γ production observed since day one of infection. This early cytokine production was largely abrogated in IL-12/IL23 p40-deficient mice. Moreover, production of IFN-γ by stromal vascular fraction cells isolated from these mice was markedly lower than that of wild-type counterparts upon stimulation with parasite antigen. In wild-type mice the increased IFN-γ production was concomitant with up-regulated expression of genes encoding interferon-inducible GTPases and nitric oxide synthase, which are important effector molecules in controlling intracellular parasite growth. This increased gene expression was markedly impaired in the p40-deficient mice. Overall, these results show that NK cells but also diverse T cell populations mediate a prompt and widespread production of IFN-γ in the adipose tissue of N. caninum infected mice.
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