Evidence map›Paper›PMID 27001291›Full record

ArticleScientific reports2016

Human gut colonisation may be initiated in utero by distinct microbial communities in the placenta and amniotic fluid.

Maria Carmen Collado, Samuli Rautava, Juhani Aakko, Erika Isolauri, Seppo Salminen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 564 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
564citing papers in PubMed, 4 pooled it
63.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

564 citing papers in PubMed, 4 syntheses or guidelines pooled it, 1,065 citations in OpenAlex.

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  19. The Gut in Early Life-Postnatal Challenges.Children (Basel, Switzerland) · 2026
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504 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Maria Carmen ColladoFunctional Foods Forum, University of Turku, Itäinen Pitkäkatu 4A, 20520, Turku, Finland.
Samuli RautavaDepartment of Paediatrics, University of Turku and Turku University Hospital, Kiinamyllynkatu 4-8, 20520, Turku, Finland.
Juhani AakkoFunctional Foods Forum, University of Turku, Itäinen Pitkäkatu 4A, 20520, Turku, Finland.
Erika IsolauriDepartment of Paediatrics, University of Turku and Turku University Hospital, Kiinamyllynkatu 4-8, 20520, Turku, Finland.
Seppo SalminenFunctional Foods Forum, University of Turku, Itäinen Pitkäkatu 4A, 20520, Turku, Finland.
University of Turku · FITurku University Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interaction with intestinal microbes in infancy has a profound impact on health and disease in later life through programming of immune and metabolic pathways. We collected maternal faeces, placenta, amniotic fluid, colostrum, meconium and infant faeces samples from 15 mother-infant pairs in an effort to rigorously investigate prenatal and neonatal microbial transfer and gut colonisation. To ensure sterile sampling, only deliveries at full term by elective caesarean section were studied. Microbiota composition and activity assessment by conventional bacterial culture, 16S rRNA gene pyrosequencing, quantitative PCR, and denaturing gradient gel electrophoresis revealed that the placenta and amniotic fluid harbour a distinct microbiota characterised by low richness, low diversity and the predominance of Proteobacteria. Shared features between the microbiota detected in the placenta and amniotic fluid and in infant meconium suggest microbial transfer at the foeto-maternal interface. At the age of 3-4 days, the infant gut microbiota composition begins to resemble that detected in colostrum. Based on these data, we propose that the stepwise microbial gut colonisation process may be initiated already prenatally by a distinct microbiota in the placenta and amniotic fluid. The link between the mother and the offspring is continued after birth by microbes present in breast milk.

Indexed as

Amniotic FluidFemaleHumansInfant, NewbornIntestinesMaleMicrobiotaPlacentaPregnancy

Identifiers

PMID27001291
PMCPMC4802384
OpenAlexW2319290978

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.