ArticleBMC microbiology2016
Characterization of flagellins isolated from a highly motile strain of Lactobacillus agilis.
Article in BMC microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 35 citations in OpenAlex.
- Probiotic Bacteria in Stimulating Human Physiological Responses: Metabolic Function and Overall Health.Foods (Basel, Switzerland) · 2026Review
- The response regulator FpsR controls the flagella-pili transition and mucosal colonization inGut microbes · 2025Article
- Commensal bacterial glycosylation at the interface of host-bacteria interactions.Gut microbes · 2025Review
- Gut microbiome in metabolic dysfunction-associated steatotic liver disease and associated hepatocellular carcinoma.Nature reviews. Gastroenterology & hepatology · 2025Review
- Harnessing flagellin ofApplied and environmental microbiology · 2025Article
- Complete genome sequence ofJournal of animal science and technology · 2025Article
- A Two-Faced Gut Microbiome: Butyrogenic and Proinflammatory Bacteria Predominate in the Intestinal Milieu of People Living with HIV from Western Mexico.International journal of molecular sciences · 2024Article
- Ecological relevance of flagellar motility in soil bacterial communities.The ISME journal · 2024Article
- Comparative genomic analysis ofApplied and environmental microbiology · 2023Article
- Negative chemotaxis of Ligilactobacillus agilis BKN88 against gut-derived substances.Scientific reports · 2023Article
- Immunogenic Modification of Ligilactobacillus agilis by Specific Amino Acid Substitution of Flagellin.Applied and environmental microbiology · 2022Article
- Whole genome sequence analysis ofJournal of animal science and technology · 2022Article
- Genetic drift and host-adaptive features likely underlie cladogenesis of insect-associated Lachnospiraceae.Genome biology and evolution · 2022Article
- Screening of Lactic Acid Bacterial Strains with Antiviral Activity Against Porcine Epidemic Diarrhea.Probiotics and antimicrobial proteins · 2022Article
- Molecular and Cellular Mechanisms Influenced by Postbiotics.International journal of molecular sciences · 2021Review
- Isolation and Identification of a RumenMicroorganisms · 2021Article
- Stable Recombinant-Gene Expression from aApplied and environmental microbiology · 2021Article
- Dysbiosis of salivary microbiome and cytokines influence oral squamous cell carcinoma through inflammation.Archives of microbiology · 2021Article
- Gut Microbiota-Associated Activation of TLR5 Induces Apolipoprotein A1 Production in the Liver.Circulation research · 2020Article
- PCR-based screening, isolation, and partial characterization of motile lactobacilli from various animal feces.BMC microbiology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMost lactic acid bacteria are non-motile but some of them are flagellated and exhibit motility. So far, motile lactobacilli have rarely been studied, and characteristics of their flagellins are poorly understood. In this study, a highly motile strain of Lactobacillus agilis was recruited for transcriptional analysis and characterization of its flagellins.
resultsUnlike another motile lactic acid bacteria of intestinal isolate, Lactobacillus ruminis, flagellar filaments of the L. agilis strain probably consist of two homologous but distinct flagellins. Glycosylation of the flagellar filaments and their resistance to heat, acid and SDS were also observed. The immunological activity of the flagellins was evaluated through the stimulation of Caco-2 cells. The results show that TLR5-stimulating activity of the protein is attenuated, likely due to an incomplete TLR5-recognition site.
conclusionsThe flagella filaments of L. agilis BKN88 consist of two homologous glycosylated flagellins, which likely have an incomplete TLR5-recognition site. The characteristics of the flagellin are presumably a consequence of adaptation as a commensal microbe in the gastrointestinal tract.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.