ArticleBMC medicine2016
Zika virus and neurologic autoimmunity: the putative role of gangliosides.
Article in BMC medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Guillain-Barré syndrome in Colombia: where do we stand now?Immunologic research · 2017Pooled it
- Autoantibodies in COVID-19: implications for disease severity and clinical outcomes.Frontiers in immunology · 2024Review
- Biosafety and mental health: Virus induced cognitive decline.Biosafety and health · 2023Review
- A mouse model of peripheral nerve injury induced by Japanese encephalitis virus.PLoS neglected tropical diseases · 2022Article
- The clinical spectrum and immunopathological mechanisms underlying ZIKV-induced neurological manifestations.PLoS neglected tropical diseases · 2021Review
- Exome-Wide Search for Genes Associated With Central Nervous System Inflammatory Demyelinating Diseases Following CHIKV Infection: The Tip of the Iceberg.Frontiers in genetics · 2021Article
- Review
- Physiology of gangliosides and the role of antiganglioside antibodies in human diseases.Cellular & molecular immunology · 2020Review
- Study protocol for the multicentre cohorts of Zika virus infection in pregnant women, infants, and acute clinical cases in Latin America and the Caribbean: the ZIKAlliance consortium.BMC infectious diseases · 2019Observational
- Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barré Syndrome in Brazil.PLoS neglected tropical diseases · 2019Article
- Altered renal immune complexes deposition in female BWF1 lupus mice followingSaudi journal of biological sciences · 2018Article
- Divergent Roles of Antiself Antibodies during Infection.Trends in immunology · 2018Review
- Autoimmune Neurological Conditions Associated With Zika Virus Infection.Frontiers in molecular neuroscience · 2018Review
- Prevalence of IgG Autoantibodies against GD3 Ganglioside in Acute Zika Virus Infection.Frontiers in medicine · 2018Article
- Neurological Presentation of Zika Virus Infection Beyond the Perinatal Period.Current infectious disease reports · 2017Review
- Preventive and therapeutic challenges in combating Zika virus infection: are we getting any closer?Journal of neurovirology · 2017Review
- Viral Impact in Autoimmune Diseases: Expanding the "X Chromosome-Nucleolus Nexus" Hypothesis.Frontiers in immunology · 2017Article
- Quantitative proteomics reveals Piccolo as a candidate serological correlate of recovery from Guillain-Barré syndrome.Oncotarget · 2016Article
- Zika Virus Infection and Microcephaly: Evidence for a Causal Link.International journal of environmental research and public health · 2016Review
- Zika Fetal Neuropathogenesis: Etiology of a Viral Syndrome.PLoS neglected tropical diseases · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An increasing number of severe neurological complications associated with Zika virus (ZIKV), chiefly Guillain-Barré syndrome (GBS) and primary microcephaly, have led the World Health Organization to declare a global health emergency. Molecular mimicry between glycolipids and surface molecules of infectious agents explain most of the cases of GBS preceded by infection, while a direct toxicity of ZIKV on neural cells has been raised as the main mechanism by which ZIKV induces microcephaly. Gangliosides are crucial in brain development, and their expression correlates with neurogenesis, synaptogenesis, synaptic transmission, and cell proliferation. Targeting the autoimmune response to gangliosides may represent an underexploited opportunity to examine the increased incidence of neurological complications related to ZIKV infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.