ArticleNeuroscience2016
Anatomical and functional connections between the locus coeruleus and the nucleus tractus solitarius in neonatal rats.
Article in Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- The solitary nucleus connectivity to key autonomic regions in humans.The European journal of neuroscience · 2022Pooled it
- Central control of gastrointestinal functions in health and disease.Physiological reviews · 2026Review
- ASIC1a channels in the locus coeruleus mediate hypercapnic acidosis detection and COPsychopharmacology · 2026Article
- A locus coeruleus-centric framework for novelty, salience, and gamma oscillations: implications for neurostimulation, aging, and disease.Frontiers in aging neuroscience · 2026Article
- Regulation of Cardiac Function by the Autonomic Nervous System.Physiology (Bethesda, Md.) · 2025Review
- Paced Breathing Associated With Pupil Diameter Oscillations at the Same Rate and Reduced Lapses in Attention.Psychophysiology · 2025Article
- An efficient neural network of cooperating serotonergic and noradrenergic neurons in modulating sudden unexpected death in epilepsy.International journal of biological sciences · 2025Article
- Non-neuronal cholinergic system in the heart influences its homeostasis and an extra-cardiac site, the blood-brain barrier.Frontiers in cardiovascular medicine · 2024Review
- The Effect of Skeletal Muscle-Pump on Blood Pressure and Postural Control in Parkinson's Disease.Cardiovascular engineering and technology · 2023Article
- Non-invasive neuromodulation: an emerging intervention for visceral pain in gastrointestinal disorders.Bioelectronic medicine · 2023Review
- Maturational effect of leptin on COPediatric research · 2023Article
- Gastric vagal afferent signaling to the basolateral amygdala mediates anxiety-like behaviors in experimental colitis mice.JCI insight · 2023Article
- Vagus nerve stimulation parameters evoke differential neuronal responses in the locus coeruleus.Physiological reports · 2023Article
- Properties and modulation of excitatory inputs to the locus coeruleus.The Journal of physiology · 2022Article
- When the Locus Coeruleus Speaks Up in Sleep: Recent Insights, Emerging Perspectives.International journal of molecular sciences · 2022Review
- The omnipresence of autonomic modulation in health and disease.Progress in neurobiology · 2022Review
- Effect of Parkinson's Disease on Cardio-postural Coupling During Orthostatic Challenge.Frontiers in physiology · 2022Article
- Respiratory Control by Phox2b-expressing Neurons in a Locus Coeruleus-preBötzinger Complex Circuit.Neuroscience bulletin · 2021Article
- Rapid and transient enhancement of thalamic information transmission induced by vagus nerve stimulation.Journal of neural engineering · 2020Article
- Afferent neural feedback overrides the modulating effects of arousal, hypercapnia and hypoxaemia on neonatal cardiorespiratory control.The Journal of physiology · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
This study was designed to investigate brain connections among chemosensitive areas in newborn rats. Rhodamine beads were injected unilaterally into the locus coeruleus (LC) or into the caudal part of the nucleus tractus solitarius (cNTS) in Sprague-Dawley rat pups (P7-P10). Rhodamine-labeled neurons were patched in brainstem slices to study their electrophysiological responses to hypercapnia and to determine if chemosensitive neurons are communicating between LC and cNTS regions. After 7-10 days, retrograde labeling was observed in numerous areas of the brainstem, including many chemosensitive regions, such as the contralateral LC, cNTS and medullary raphe. Whole-cell patch clamp was done in cNTS. In 4 of 5 retrogradely labeled cNTS neurons that projected to the LC, firing rate increased in response to hypercapnic acidosis (15% CO2), even in synaptic blockade medium (SNB) (high Mg(2+)/low Ca(2+)). In contrast, 2 of 3 retrogradely labeled LC neurons that projected to cNTS had reduced firing rate in response to hypercapnic acidosis, both in the presence and absence of SNB. Extensive anatomical connections among chemosensitive brainstem regions in newborn rats were found and at least for the LC and cNTS, the connections involve some CO2-sensitive neurons. Such anatomical and functional coupling suggests a complex central respiratory control network, such as seen in adult rats, is already largely present in neonatal rats by at least day P7-P10. Since the NTS and the LC play a major role in memory consolidation, our results may also contribute to the understanding of the development of memory consolidation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.