ArticleActa neuropathologica communications2016
Pneumococcal meningitis: clinical-pathological correlations (MeninGene-Path).
Article in Acta neuropathologica communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 82 citations in OpenAlex.
- Bioengineered Extracellular Vesicles Mitigate Neuroinflammation by Neutralizing Pneumolysin and Delaying Disease Onset in Experimental Pneumococcal Meningitis.Journal of extracellular vesicles · 2026Article
- Cerebral Venous Sinus Thrombosis Following Pneumococcal Meningitis: A Rare but Serious Complication.Cureus · 2026Article
- Prevalence and outcomes of cerebral vasculitis in patients with comatose ventilated meningitis in the dexamethasone era.BMC research notes · 2026Article
- mTORC1 inhibition by sirolimus as adjunctive treatment in experimental pneumococcal meningitis.Brain communications · 2026Article
- Pneumococcal meningitis secondary to chronic orbital inflammation with skull base erosion: a case report.Frontiers in medicine · 2026Article
- Article
- Role of the Ear in Meningitis: A Narrative Review of Neuroimaging.Diagnostics (Basel, Switzerland) · 2025Review
- Cochlear hemorrhage in a patient with pneumococcal meningitis.Acta neurologica Belgica · 2025Article
- Cohort study exploring the association of cerebrospinal fluid metalloprotease levels and Microbiological characteristics to cerebral vasculitis complication in Pneumococcal meningitis.Scientific reports · 2025Observational
- Cerebral vasculitis secondary to pneumococcal meningitis. Plasmapheresis as adjuvant therapy. Case report.Anaesthesiology intensive therapy · 2025Article
- Cerebrovascular Complications in Bacterial Meningitis.Stroke (Hoboken, N.J.) · 2025Review
- Post-Meningitic Syndrome: Pathophysiology and Consequences of Streptococcal Infections on the Central Nervous System.International journal of molecular sciences · 2024Review
- Biomechanical instability of the brain-CSF interface in hydrocephalus.Brain : a journal of neurology · 2024Review
- Adjunctive treatments for pneumococcal meningitis: a systematic review of experimental animal models.Brain communications · 2024Review
- Pericytes are protective in experimental pneumococcal meningitis through regulating leukocyte infiltration and blood-brain barrier function.Journal of neuroinflammation · 2023Article
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- Article
- Uncovering the neuroprotective effect of vitamin B12 in pneumococcal meningitis: insights into its pleiotropic mode of action at the transcriptional level.Frontiers in immunology · 2023Article
- Interleukin-17A Contributed to the Damage of Blood-CNS Barriers During Streptococcus suis Meningitis.Molecular neurobiology · 2022Article
- Early Intracranial Hemorrhage Predicts Poor Clinical Outcome in Community-Acquired Bacterial Meningitis.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Pneumococcal meningitis is associated with substantial mortality and morbidity. We systematically assessed brain histopathology of 31 patients who died of pneumococcal meningitis from a nationwide study (median age 67 years; 21 (67 %) were male) using a pathology score including inflammation and vascular damage. Of the 27 patients with known time from the admission to death, 14 patients died within 7 days of admission and 13 after 7 days of admission. Eleven of 25 (44 %) patients had been treated with adjunctive dexamethasone therapy. Observed pathological processes were inflammation of medium-large arteries in 30 brains (97 %), cerebral haemorrhage in 24 (77 %), cerebritis in 24 (77 %), thrombosis in 21 (68 %), infarction in 19 (61 %) and ventriculitis in 19 (of 28 cases, 68 %). Inflammation of medium-large arteries led to obstruction of the vascular lumen in 14 (of 31 cases, 45 %). Vascular inflammation was associated with infarction and thrombosis of brain parenchymal vessels. Hippocampal dentate gyrus apoptosis between patients treated with and without dexamethasone was similar (p = 0.66); however, dexamethasone treated patients had higher total pathology score than non-dexamethasone treated patients (p = 0.003). Our study shows that vascular damage is key in the process of brain damage in pneumococcal meningitis. Data and material of this study will be made open-access for translational research in pneumococcal meningitis (MeninGene-Path).
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Registered trials
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