Observational studyInternational wound journal2017
Management of enteroatmospheric fistula with negative pressure wound therapy in open abdomen treatment: a multicentre observational study.
Observational study in International wound journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Chinese Trauma Surgeon Association for management guidelines of vacuum sealing drainage application in abdominal surgeries-Update and systematic review.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2019Pooled it
- Enterocutaneous Fistulas: Current Management.Nutrients · 2026Review
- Negative pressure mechanical signal increases the phosphorylation of eNOS Ser1177 by upregulating HSP90 expression to promote wound angiogenesis.Journal of advanced research · 2026Article
- A low-cost customized silicone floating stoma for the management of high-output entero-atmospheric fistula: a case report.Journal of surgical case reports · 2026Article
- Late closure of the open abdomen in emergency abdomino-pelvic surgery: Advanced indications to negative pressure wound therapy?World journal of emergency surgery : WJES · 2025Article
- Article
- Effectiveness of vacuum-assisted wound closure and mesh-mediated fascial traction in open abdomen management.Surgery today · 2025Article
- Entero-Cutaneous and Entero-Atmospheric Fistulas: Insights into Management Using Negative Pressure Wound Therapy.Journal of clinical medicine · 2024Review
- Personalized additive manufacturing of devices for the management of enteroatmospheric fistulas.Bioengineering & translational medicine · 2023Article
- A 5 + 1-Axis 3D Printing Platform for Producing Customized Intestinal Fistula Stents.3D printing and additive manufacturing · 2023Article
- Dynamic Kinesiotherapy: A Novel Technique That Promotes Appropriate Abdominal Wound Healing.Cureus · 2023Article
- Failure to Rescue (FTR) and Pitfalls in the Management of Complex Enteric Fistulas (CEF): From Rescue Surgery to Rescue Strategy.Journal of personalized medicine · 2022Article
- Effect of closed incision negative pressure wound therapy on incidence rate of surgical site infection after stoma reversal: a pilot study.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2021Article
- A New Extraperitoneal Method for Entero-atmospheric Fistula Closure Using a Free Muscle Flap.Plastic and reconstructive surgery. Global open · 2021Article
- The Association of Coloproctology of Great Britain and Ireland consensus guidelines in emergency colorectal surgery.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2021Article
- Ehlers-Danlos syndrome type IV: a case report of a rare cause of spontaneous sigmoid perforation and enteroatmospheric fistulae in a child.Surgical case reports · 2020Article
- Using a bio-scanner and 3D printing to create an innovative custom made approach for the management of complex entero-atmospheric fistulas.Scientific reports · 2020Article
- The successful management for long-term intractable enteroatmospheric fistula: A case report.Annals of medicine and surgery (2012) · 2020Article
- Innovative approach to open abdomen: converting an enteroatmospheric fistula into an easily manageable stoma.BMJ case reports · 2020Article
- LapVac - a laparoscopic approach for negative pressure wound therapy application in open abdomen management: a porcine animal model.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The management of enteroatmospheric fistula (EAF) in open abdomen (OA) therapy is challenging and associated with a high mortality rate. The introduction of negative pressure wound therapy (NPWT) in open abdomen management significantly improved the healing process and increased spontaneous fistula closure. Retrospectively, we analysed 16 patients with a total of 31 enteroatmospheric fistulas in open abdomen management who were treated using NPWT in four referral centres between 2004 and 2014. EAFs were diagnosed based on clinical examination and confirmed with imaging studies and classified into low (<200 ml/day), moderate (200-500 ml/day) and high (>500 ml/day) output fistulas. The study group consisted of five women and 11 men with the mean age of 52·6 years [standard deviation (SD) 11·9]. Since open abdomen management was implemented, the mean number of re-surgeries was 3·7 (SD 2·2). There were 24 EAFs located in the small bowel, while four were located in the colon. In three patients, EAF occurred at the anastomotic site. Thirteen fistulas were classified as low output (41·9%), two as moderate (6·5%) and 16 as high output fistulas (51·6%). The overall closure rate was 61·3%, with a mean time of 46·7 days (SD 43·4). In the remaining patients in whom fistula closure was not achieved (n = 12), a protruding mucosa was present. Analysing the cycle of negative pressure therapy, we surprisingly found that the spontaneous closure rate was 70% (7 of 10 EAFs) using intermittent setting of negative pressure, whereas in the group of patients treated with continuous pressure, 57% of EAFs closed spontaneously (12 of 21 EAFs). The mean number of NPWT dressing was 9 (SD 3·3; range 4-16). In two patients, we observed new fistulas that appeared during NPWT. Three patients died during therapy as a result of multi-organ failure. NPWT is a safe and efficient method characterised by a high spontaneous closure rate. However, in patients with mucosal protrusion of the EAFs, spontaneous closure appears to be impossible to achieve.
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