ArticleScientific reports2016
An Integrated Genomic Strategy Delineates Candidate Mediator Genes Regulating Grain Size and Weight in Rice.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 30 citations in OpenAlex.
- A genome-wide association analysis identifies a key candidate gene controlling plant growth habit in chickpea.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Integrating transcriptomics and proteomics to analyze new regulatory genes related to rice grain development.Food chemistry. Molecular sciences · 2025Article
- The Mediator subunit OsMED23 associates with the histone demethylase OsJMJ703 and the transcription factor OsWOX3A to control grain size and yield in rice.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Uncovering DNA methylation landscapes to decipher evolutionary footprints of phenotypic diversity in chickpea.DNA research : an international journal for rapid publication of reports on genes and genomes · 2024Article
- A superior gene allele involved in abscisic acid signaling enhances drought tolerance and yield in chickpea.Plant physiology · 2023Article
- Identification and molecular characterization of miRNAs and their target genes associated with seed development through small RNA sequencing in chickpea.Functional & integrative genomics · 2021Article
- Comparative Genomic Analysis of Quantitative Trait Loci Associated With Micronutrient Contents, Grain Quality, and Agronomic Traits in Wheat (Frontiers in plant science · 2021Article
- Genetic Analysis of Agronomic Traits and Grain Iron and Zinc Concentrations in a Doubled Haploid Population of Rice (Oryza sativa L.).Scientific reports · 2020Article
- Genome-wide cis-regulatory signatures for modulation of agronomic traits as exemplified by drought yield index (DYI) in chickpea.Functional & integrative genomics · 2019Article
- Sequencing of Chinese castor lines reveals genetic signatures of selection and yield-associated loci.Nature communications · 2019Article
- CLAVATA signaling pathway genes modulating flowering time and flower number in chickpea.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2019Article
- ABC Transporter-Mediated Transport of Glutathione Conjugates Enhances Seed Yield and Quality in Chickpea.Plant physiology · 2019Article
- Analysis of Rice Proteins with DLN Repressor Motif/S.International journal of molecular sciences · 2019Article
- Genome-wide generation and genotyping of informative SNPs to scan molecular signatures for seed yield in chickpea.Scientific reports · 2018Article
- Article
- Rice grain nutritional traits and their enhancement using relevant genes and QTLs through advanced approaches.SpringerPlus · 2016Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study deployed a Mediator (MED) genes-mediated integrated genomic strategy for understanding the complex genetic architecture of grain size/weight quantitative trait in rice. The targeted multiplex amplicon resequencing of 55 MED genes annotated from whole rice genome in 384 accessions discovered 3971 SNPs, which were structurally and functionally annotated in diverse coding and non-coding sequence-components of genes. Association analysis, using the genotyping information of 3971 SNPs in a structured population of 384 accessions (with 50-100 kb linkage disequilibrium decay), detected 10 MED gene-derived SNPs significantly associated (46% combined phenotypic variation explained) with grain length, width and weight in rice. Of these, one strong grain weight-associated non-synonymous SNP (G/A)-carrying OsMED4_2 gene was validated successfully in low- and high-grain weight parental accessions and homozygous individuals of a rice mapping population. The seed-specific expression, including differential up/down-regulation of three grain size/weight-associated MED genes (including OsMED4_2) in six low and high-grain weight rice accessions was evident. Altogether, combinatorial genomic approach involving haplotype-based association analysis delineated diverse functionally relevant natural SNP-allelic variants in 10 MED genes, including three potential novel SNP haplotypes in an OsMED4_2 gene governing grain size/weight differentiation in rice. These molecular tags have potential to accelerate genomics-assisted crop improvement in rice.
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