ArticleThe Journal of pharmacology and experimental therapeutics2016
Pharmacology of Bradykinin-Evoked Coughing in Guinea Pigs.
Article in The Journal of pharmacology and experimental therapeutics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- Physiological mechanisms and therapeutic targets in chronic cough.Physiological reports · 2026Review
- Therapeutic Targeting of the Bradykinin B2 Receptor in Immunological and Vascular Diseases: Insights from Kinin Biology to Clinical Outcomes.Clinical reviews in allergy & immunology · 2026Review
- Nitric oxide synthase activation in nTS is essential to NMDA receptor dependent encoding of the cough reflex.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- Genomics of chronic dry cough unravels neurological pathways.The European respiratory journal · 2025Article
- Article
- Methods of Cough Assessment and Objectivization.Physiological research · 2023Review
- Infectious and Inflammatory Pathways to Cough.Annual review of physiology · 2023Review
- Cough hypersensitivity and chronic cough.Nature reviews. Disease primers · 2022Review
- Evidence for AlphaThe Journal of pharmacology and experimental therapeutics · 2022Article
- How the Innate Immune System of the Blood Contributes to Systemic Pathology in COVID-19-Induced ARDS and Provides Potential Targets for Treatment.Frontiers in immunology · 2022Review
- Prostaglandin ERespiratory research · 2021Article
- Oral nano-curcumin formulation efficacy in the management of mild to moderate outpatient COVID-19: A randomized triple-blind placebo-controlled clinical trial.Food science & nutrition · 2021Article
- Characterisation of cough evoked by inhaled treprostinil and treprostinil palmitil.ERJ open research · 2021Article
- Descending Modulation of Laryngeal Vagal Sensory Processing in the Brainstem Orchestrated by the Submedius Thalamic Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Article
- Curcumin (a constituent of turmeric): New treatment option against COVID-19.Food science & nutrition · 2020Review
- Drug-Induced Cough.Physiological research · 2020Review
- Bradykinin sensitizes the cough reflex via a BRespiratory research · 2019Article
- Vagal Afferent Processing by the Paratrigeminal Nucleus.Frontiers in physiology · 2019Review
- Opposing effects of bronchopulmonary C-fiber subtypes on cough in guinea pigs.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Bradykinin has been implicated as a mediator of the acute pathophysiological and inflammatory consequences of respiratory tract infections and in exacerbations of chronic diseases such as asthma. Bradykinin may also be a trigger for the coughing associated with these and other conditions. We have thus set out to evaluate the pharmacology of bradykinin-evoked coughing in guinea pigs. When inhaled, bradykinin induced paroxysmal coughing that was abolished by the bradykinin B2 receptor antagonist HOE 140. These cough responses rapidly desensitized, consistent with reports of B2 receptor desensitization. Bradykinin-evoked cough was potentiated by inhibition of both neutral endopeptidase and angiotensin-converting enzyme (with thiorphan and captopril, respectively), but was largely unaffected by muscarinic or thromboxane receptor blockade (atropine and ICI 192605), cyclooxygenase, or nitric oxide synthase inhibition (meclofenamic acid and N(G)-nitro-L-arginine). Calcium influx studies in bronchopulmonary vagal afferent neurons dissociated from vagal sensory ganglia indicated that the tachykinin-containing C-fibers arising from the jugular ganglia mediate bradykinin-evoked coughing. Also implicating the jugular C-fibers was the observation that simultaneous blockade of neurokinin2 (NK2; SR48968) and NK3 (SR142801 or SB223412) receptors nearly abolished the bradykinin-evoked cough responses. The data suggest that bradykinin induces coughing in guinea pigs by activating B2 receptors on bronchopulmonary C-fibers. We speculate that therapeutics targeting the actions of bradykinin may prove useful in the treatment of cough.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.