Trial reportNeuromodulation : journal of the International Neuromodulation Society2016
Randomized, Blinded Pilot Testing of Nonconventional Stimulation Patterns and Shapes in Parkinson's Disease and Essential Tremor: Evidence for Further Evaluating Narrow and Biphasic Pulses.
Trial report in Neuromodulation : journal of the International Neuromodulation Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07410598 (Safety and Tolerability of Patterned Stimulation for DBS in the Home Setting), which is not on this map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Safety and Tolerability of Patterned Stimulation for DBS in the Home Setting
Who cites it
35 citing papers in PubMed.
- Individualized Frequency-Dependent Stimulation to the Anterior Nucleus of the Thalamus May Improve Antiepileptic Effects in Patients With Focal Epilepsy.CNS neuroscience & therapeutics · 2025Article
- Pilot Study of Acute Behavioral Effects of Pallidal Burst Stimulation in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2024Article
- Review
- Active recharge biphasic stimulation for the intraoperative monopolar review in deep brain stimulation.Frontiers in human neuroscience · 2024Article
- Machine learning for adaptive deep brain stimulation in Parkinson's disease: closing the loop.Journal of neurology · 2023Review
- Comparison of subthalamic unilateral and bilateral theta burst deep brain stimulation in Parkinson's disease.Frontiers in human neuroscience · 2023Article
- Myogenic and cortical evoked potentials vary as a function of stimulus pulse geometry delivered in the subthalamic nucleus of Parkinson's disease patients.Frontiers in neurology · 2023Article
- Alternative patterns of deep brain stimulation in neurologic and neuropsychiatric disorders.Frontiers in neuroinformatics · 2023Review
- Deep brain-machine interfaces: sensing and modulating the human deep brain.National science review · 2022Review
- Subthalamic nucleus deep brain stimulation driven by primary motor cortex γ2 activity in parkinsonian monkeys.Scientific reports · 2022Article
- Past, Present, and Future of Deep Brain Stimulation: Hardware, Software, Imaging, Physiology and Novel Approaches.Frontiers in neurology · 2022Review
- Benchtop and bedside validation of a low-cost programmable cortical stimulator in a testbed for bi-directional brain-computer-interface research.Frontiers in neuroscience · 2022Article
- An Anodic Phase Can Facilitate Rather Than Weaken a Cathodic Phase to Activate Neurons in Biphasic-Pulse Axonal Stimulations.Frontiers in neuroscience · 2022Article
- Wearable and Implantable Electroceuticals for Therapeutic Electrostimulations.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Technology of deep brain stimulation: current status and future directions.Nature reviews. Neurology · 2021Review
- Digital Health Integration With Neuromodulation Therapies: The Future of Patient-Centric Innovation in Neuromodulation.Frontiers in digital health · 2021Review
- Safety and Tolerability of Burst-Cycling Deep Brain Stimulation for Freezing of Gait in Parkinson's Disease.Frontiers in human neuroscience · 2021Article
- Implantable Pulse Generators for Deep Brain Stimulation: Challenges, Complications, and Strategies for Practicality and Longevity.Frontiers in human neuroscience · 2021Article
- Time-dynamic pulse modulation of spinal cord stimulation reduces mechanical hypersensitivity and spontaneous pain in rats.Scientific reports · 2020Article
- Optimal Parameters of Deep Brain Stimulation in Essential Tremor: A Meta-Analysis and Novel Programming Strategy.Journal of clinical medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectivesEvidence suggests that nonconventional programming may improve deep brain stimulation (DBS) therapy for movement disorders. The primary objective was to assess feasibility of testing the tolerability of several nonconventional settings in Parkinson's disease (PD) and essential tremor (ET) subjects in a single office visit. Secondary objectives were to explore for potential efficacy signals and to assess the energy demand on the implantable pulse-generators (IPGs). MATERIALS AND
methodsA custom firmware (FW) application was developed and acutely uploaded to the IPGs of eight PD and three ET subjects, allowing delivery of several nonconventional DBS settings, including narrow pulse widths, square biphasic pulses, and irregular pulse patterns. Standard clinical rating scales and several objective measures were used to compare motor outcomes with sham, clinically-optimal and nonconventional settings. Blinded and randomized testing was conducted in a traditional office setting.
resultsOverall, the nonconventional settings were well tolerated. Under these conditions it was also possible to detect clinically-relevant differences in DBS responses using clinical rating scales but not objective measures. Compared to the clinically-optimal settings, some nonconventional settings appeared to offer similar benefit (e.g., narrow pulse widths) and others lesser benefit. Moreover, the results suggest that square biphasic pulses may deliver greater benefit. No unexpected IPG efficiency disadvantages were associated with delivering nonconventional settings.
conclusionsIt is feasible to acutely screen nonconventional DBS settings using controlled study designs in traditional office settings. Simple IPG FW upgrades may provide more DBS programming options for optimizing therapy. Potential advantages of narrow and biphasic pulses deserve follow up.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.