Evidence map›Paper›PMID 27000754›Full record

ReviewHeart failure reviews2017

Diaphragm abnormalities in heart failure and aging: mechanisms and integration of cardiovascular and respiratory pathophysiology.

Rachel C Kelley, Leonardo F Ferreira

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Heart failure reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 115 citations in OpenAlex.

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  13. Motor Dysfunctions in Fibromyalgia Patients: The Importance of Breathing.Open access rheumatology : research and reviews · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rachel C KelleyDepartment of Applied Physiology and Kinesiology, University of Florida, 1864 Stadium Rd., rm 100 FLG, Gainesville, FL, 32611-8205, USA.
Leonardo F FerreiraDepartment of Applied Physiology and Kinesiology, University of Florida, 1864 Stadium Rd., rm 100 FLG, Gainesville, FL, 32611-8205, USA. ferreira@hhp.ufl.edu.
University of Florida · US

Funding

Redox basis of diaphragm mitochondrial dysfunction and atrophy in heart failureR01HL130318 · NHLBI · UNIVERSITY OF FLORIDA · PI FERREIRA, LEONARDO · 2016 to 2025
$3.9M
Mechanisms of Respiratory Muscle Dysfunction in Heart FailureR00HL098453 · NHLBI · UNIVERSITY OF FLORIDA · PI FERREIRA, LEONARDO · 2011 to 2013
$735k
NHLBI NIH HHS R00 HL098453NHLBI NIH HHS R01 HL130318
6 · The paper itself

Abstract

Inspiratory function is essential for alveolar ventilation and expulsive behaviors that promote airway clearance (e.g., coughing and sneezing). Current evidence demonstrates that inspiratory dysfunction occurs during healthy aging and is accentuated by chronic heart failure (CHF). This inspiratory dysfunction contributes to key aspects of CHF and aging cardiovascular and pulmonary pathophysiology including: (1) impaired airway clearance and predisposition to pneumonia; (2) inability to sustain ventilation during physical activity; (3) shallow breathing pattern that limits alveolar ventilation and gas exchange; and (4) sympathetic activation that causes cardiac arrhythmias and tissue vasoconstriction. The diaphragm is the primary inspiratory muscle; hence, its neuromuscular integrity is a main determinant of the adequacy of inspiratory function. Mechanistic work within animal and cellular models has revealed specific factors that may be responsible for diaphragm neuromuscular abnormalities in CHF and aging. These include phrenic nerve and neuromuscular junction alterations as well as intrinsic myocyte abnormalities, such as changes in the quantity and quality of contractile proteins, accelerated fiber atrophy, and shifts in fiber type distribution. CHF, aging, or CHF in the presence of aging disturbs the dynamics of circulating factors (e.g., cytokines and angiotensin II) and cell signaling involving sphingolipids, reactive oxygen species, and proteolytic pathways, thus leading to the previously listed abnormalities. Exercise-based rehabilitation combined with pharmacological therapies targeting the pathways reviewed herein hold promise to treat diaphragm abnormalities and inspiratory muscle dysfunction in CHF and aging.

Indexed as

AgingHeart FailureAnimalsDiaphragmDyspneaExerciseExercise TherapyExercise ToleranceHumansDyspneaExercise toleranceFatigueFiber atrophyRespiratory muscleWeakness

Identifiers

PMID27000754
PMCPMC4827708
OpenAlexW2308650844

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.