Evidence map›Paper›PMID 27000523›Full record

ArticleNature communications2016

Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain.

Hiromu Monai, Masamichi Ohkura, Mika Tanaka, Yuki Oe, Ayumu Konno, Hirokazu Hirai, Katsuhiko Mikoshiba, Shigeyoshi Itohara, Junichi Nakai, Youichi Iwai and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 190 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
190citing papers in PubMed, 6 pooled it
23.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

190 citing papers in PubMed, 6 syntheses or guidelines pooled it, 425 citations in OpenAlex.

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  9. The neuromodulatory effect of tDCS in patients affected by functional motor symptoms: an exploratory study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019
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  19. Neuromodulation and cognition in late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
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130 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Hiromu MonaiRIKEN Brain Science Institute, 2-1 Wako, Saitama 351-0198, Japan.
Masamichi OhkuraBrain Science Institute, Saitama University, Saitama 338-8570, Japan.
Mika TanakaRIKEN Brain Science Institute, 2-1 Wako, Saitama 351-0198, Japan.
Yuki OeRIKEN Brain Science Institute, 2-1 Wako, Saitama 351-0198, Japan.
Ayumu KonnoDepartment of Neurophysiology and Neural Repair, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan.
Hirokazu HiraiDepartment of Neurophysiology and Neural Repair, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan.
Katsuhiko MikoshibaRIKEN Brain Science Institute, 2-1 Wako, Saitama 351-0198, Japan.
Shigeyoshi ItoharaRIKEN Brain Science Institute, 2-1 Wako, Saitama 351-0198, Japan.
Junichi NakaiBrain Science Institute, Saitama University, Saitama 338-8570, Japan.
Youichi IwaiRIKEN Brain Science Institute, 2-1 Wako, Saitama 351-0198, Japan.
Hajime HiraseRIKEN Brain Science Institute, 2-1 Wako, Saitama 351-0198, Japan.ORCID http://orcid.org/0000-0003-3806-6905
RIKEN Center for Brain Science · JPGunma University · JPSaitama University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcranical direct current stimulation (tDCS) is a treatment known to ameliorate various neurological conditions and enhance memory and cognition in humans. tDCS has gained traction for its potential therapeutic value; however, little is known about its mechanism of action. Using a transgenic mouse expressing G-CaMP7 in astrocytes and a subpopulation of excitatory neurons, we find that tDCS induces large-amplitude astrocytic Ca(2+) surges across the entire cortex with no obvious changes in the local field potential. Moreover, sensory evoked cortical responses are enhanced after tDCS. These enhancements are dependent on the alpha-1 adrenergic receptor and are not observed in IP3R2 (inositol trisphosphate receptor type 2) knockout mice, in which astrocytic Ca(2+) surges are absent. Together, we propose that tDCS changes the metaplasticity of the cortex through astrocytic Ca(2+)/IP3 signalling.

Indexed as

Transcranial Direct Current StimulationAnimalsAstrocytesCalciumCalcium SignalingCerebral CortexEvoked PotentialsGreen Fluorescent ProteinsInositol 1,4,5-Trisphosphate ReceptorsMiceMice, KnockoutMice, TransgenicNeurogliaNeuronal PlasticityOptical ImagingReceptors, Adrenergic, alpha-1CalciumGreen Fluorescent ProteinsInositol 1,4,5-Trisphosphate ReceptorsIp3r2 protein, mouseReceptors, Adrenergic, alpha-1

Identifiers

PMID27000523
PMCPMC4804173
OpenAlexW2310204605

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.