Evidence map›Paper›PMID 27000393›Full record

ReviewKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2016

Early osteoarthritis of the knee.

Henning Madry, Elizaveta Kon, Vincenzo Condello, Giuseppe M Peretti, Matthias Steinwachs, Romain Seil, Massimo Berruto, Lars Engebretsen, Giuseppe Filardo, Peter Angele

Abstract readReview
PubMed Publisher
In one paragraph

Review in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
147citing papers in PubMed, 13 pooled it
16.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

147 citing papers in PubMed, 13 syntheses or guidelines pooled it, 297 citations in OpenAlex.

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  12. Microfracture for cartilage repair in the knee: a systematic review of the contemporary literature.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2020
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  14. Effects of Sanqi Shengyu External Application Cream and Pulsed Electromagnetic Field on Knee Osteoarthritis in Older Adults: A Randomized Controlled Trial.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026
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87 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 10 institutions in 6 countries.

Henning MadryCenter of Experimental Orthopaedics, Saarland University, Kirrberger Strasse 100, Building 37-38, 66421, Homburg/Saar, Germany. henning.madry@uks.eu.
Elizaveta KonNABI Laboratory, Rizzoli Orthopaedic Institute, Via Di Barbiano, 1/10, 40136, Bologna, Italy.
Vincenzo CondelloDipartimento di Ortopedia, Responsabile di Struttura Semplice di Traumatologia dello, Sport Knee Surgery and Sports Traumatology, Ospedale Sacro Cuore - Don Calabria, Via Don, Sempreboni, 5, 37024, Negrar, Verona, Italy.
Giuseppe M PerettiIRCCS Istituto Ortopedico Galeazzi, Milan, Italy.
Matthias SteinwachsSportClinic Zürich, Klinik Hirslanden, Witellikerstrasse 40, 8032, Zurich, Switzerland.
Romain SeilService de Chirurgie Orthopédique, Centre de L'Appareil Locomoteur, de Médecine du Sport et de Prévention, Centre Hospitalier de Luxembourg-Clinique d'Eich and Sports Medicine Research Laboratory, Luxembourg Institute of Health, 78, rue d'Eich, 1460, Luxembourg, Luxembourg.
Massimo BerrutoCentro di Eccellenza per L'attività Ortopedica, Reumatologica e Riabilitativa, L'Istituto Ortopedico Gaetano Pini è un'Azienda Ospedaliera di rilievo nazionale, P.zza A. Ferrari, 1, 20122, Milan, Italy.
Lars EngebretsenDepartment of Orthopedic Surgery, Oslo University Hospital and Oslo Sports Trauma Research Center, 0407, Oslo, Norway.
Giuseppe FilardoBiomechanics Laboratory, II Orthopaedics and Traumatology Clinic, Rizzoli Orthopaedic Institute, Via Di Barbiano, 1/10, 40136, Bologna, Italy.
Peter AngeleDepartment of Trauma Surgery, University Medical Center Regensburg, Franz-Josef-Strauss-Allee 11, 93042, Regensburg, Germany.
Centre Hospitalier de Luxembourg · LUIstituto Ortopedico Gaetano Pini · ITIstituto Ortopedico Galeazzi · ITIstituto Ortopedico Rizzoli · ITKlinik Hirslanden · CHOrthopedic Institute · USOslo Sports Trauma Research Center · NOOspedale Sacro Cuore Don Calabria · ITRegensburg University of Applied Sciences · DESaarland University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is an increasing awareness on the importance in identifying early phases of the degenerative processes in knee osteoarthritis (OA), the crucial period of the disease when there might still be the possibility to initiate treatments preventing its progression. Early OA may show a diffuse and ill-defined involvement, but also originate in the cartilage surrounding a focal lesion, thus necessitating a separate assessment of these two entities. Early OA can be considered to include a maximal involvement of 50 % of the cartilage thickness based on the macroscopic ICRS classification, reflecting an OARSI grade 4. The purpose of this paper was to provide an updated review of the current status of the diagnosis and definition of early knee OA, including the clinical, radiographical, histological, MRI, and arthroscopic definitions and biomarkers. Based on current evidence, practical classification criteria are presented. As new insights and technologies become available, they will further evolve to better define and treat early knee OA.

Indexed as

ArthroscopyBiomarkersCartilage, ArticularDisease ProgressionEarly DiagnosisHumansKnee JointMagnetic Resonance ImagingOsteoarthritis, KneeRadiographyBiomarkersBiomarkersCartilageClassificationFocal cartilage defectMeniscusOAOsteochondral unitPainSubchondral boneTraumatic lesion

Identifiers

PMID27000393
OpenAlexW2310491900

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.