ArticleJournal of natural medicines2016
Euphorins A-H: bioactive diterpenoids from Euphorbia fischeriana.
Article in Journal of natural medicines, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 27 citations in OpenAlex.
- Rosanoid diterpenoids: structural diversity, classification and biological activities.ADMET & DMPK · 2026Review
- Recent Advances inMolecules (Basel, Switzerland) · 2025Review
- Phytochemical Analysis, Antioxidant Activities In Vitro and In Vivo, and Theoretical Calculation of Different Extracts ofMolecules (Basel, Switzerland) · 2023Article
- Pharmacological Potential of Lathyrane-Type Diterpenoids from Phytochemical Sources.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Integrated Strategy of UHPLC-Q-TOF-MS and Molecular Networking for Identification of Diterpenoids fromEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Estrogenic, Antiestrogenic and Antiproliferative Activities ofNutrients · 2019Article
- Structural Diversity and Biological Activities of Diterpenoids Derived fromMolecules (Basel, Switzerland) · 2018Review
- Abietane Diterpernoids from the Roots of Euphorbia ebracteolata.Natural products and bioprospecting · 2018Article
- Anti-Cancer Activities of Diterpenoids Derived from Euphorbia fischeriana Steud.Molecules (Basel, Switzerland) · 2018Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phytochemical investigation of the roots of Euphorbia fischeriana resulted in the isolation of 23 diterpenoids (1-23), which were classified into five subtypes, namely, ent-rosane (1-9), ent-abietane (10-16), ent-kaurane (17), ingenane (18-22), and lathyrane (23). The chemical structures of eight new compounds, namely, euphorin A (4), B (5), C (7), D (9), E (13), F (14), G (15), and H (16), were elucidated on the basis of extensive 1D and 2D NMR spectroscopic analyses, as well as single crystal X-ray structure analysis. A number of compounds (2, 6, 7, 10, 11, 13, 16, 19, 20, 22, and 23) showed inhibitory activity on the formation of mammospheres in human breast cancer MCF-7 cells at a final concentration of 10 μM, suggesting the potential of these bioactive diterpenoids for further investigation of the action targeting cancer stem cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.