ArticleNutrition journal2016
Development and evaluation of a test program for Y-site compatibility testing of total parenteral nutrition and intravenous drugs.
Article in Nutrition journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 60 citations in OpenAlex.
- Physical compatibility of ceftazidime-avibactam with selected intravenous antimicrobials in simulated Y-site administration.European journal of hospital pharmacy : science and practice · 2026Article
- Strategies for Assessing Physical Compatibility of Calcium Folinate with Bicarbonate During Methotrexate Rescue Therapy in Pediatric Patients with Acute Lymphoblastic Leukemia.Pharmaceutics · 2025Article
- Physical Compatibility Between Intravenous Magnesium Sulfate and Potassium or Sodium Phosphate in a Pediatric Intensive Care Unit.Hospital pharmacy · 2024Article
- Potential Use of Common Administration of Emulsion for Parenteral Nutrition and Vinpocetine: Compatibility Study and Prospect.Metabolites · 2024Article
- Y-Site Compatibility Studies of Parenteral Nutrition and Other Intravenous Medications in Neonatal and Pediatric Patients: A Review of the Literature Evidence.Pharmaceutics · 2024Review
- Harmonising IV Oxycodone with Paediatric Perioperative Medications: A Compatibility Study Through Y-Type Connectors.Drug design, development and therapy · 2024Article
- Use of Total Parenteral Nutrition (TPN) as a Vehicle for Drug Delivery.Current drug targets · 2024Review
- Antiemetic Drugs Compatibility Evaluation with Paediatric Parenteral Nutrition Admixtures.Pharmaceutics · 2023Article
- Co-administration of Intravenous Drugs: Rapidly Troubleshooting the Solid Form Composition of a Precipitate in a Multi-drug Mixture Using On-Site Raman Spectroscopy.Molecular pharmaceutics · 2023Article
- The Physical Compatibility of Glycopyrrolate and Rocuronium.Anesthesia progress · 2023Article
- Exploring a case of incompatibility in a complex regimen containing Plasma-Lyte 148 in the pediatric intensive care.Paediatric anaesthesia · 2023Article
- Assessment of compatibility of rhIGF-1/rhIGFBP-3 with neonatal intravenous medications.World journal of pediatrics : WJP · 2023Article
- Frequently acquired drugs in neonatal intensive care and their physical compatibility.Acta paediatrica (Oslo, Norway : 1992) · 2022Article
- Y-Site Compatibility Studies of Ketoprofen with Parenteral Nutrition Admixtures for Central and Peripheral Administration.Pharmaceutics · 2022Article
- Co-administration of drugs with parenteral nutrition in the neonatal intensive care unit-physical compatibility between three components.European journal of pediatrics · 2022Article
- Sodium Valproate Incompatibility with Parenteral Nutrition Admixtures-A Risk to Patient Safety: An In Vitro Evaluation Study.Pharmaceutics · 2022Article
- Y-Site Compatibility of Intravenous Levetiracetam With Commonly Used Critical Care Medications.Hospital pharmacy · 2021Article
- All-in-One Pediatric Parenteral Nutrition Admixtures with an Extended Shelf Life-Insight in Correlations between Composition and Physicochemical Parameters.Pharmaceutics · 2021Article
- Stability and Compatibility Aspects of Drugs: The Case of Selected Cephalosporins.Antibiotics (Basel, Switzerland) · 2021Article
- Physical compatibility of alprostadil with selected drugs commonly used in the neonatal intensive care units.European journal of pediatrics · 2021Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is no standardized procedure or consensus to which tests should be performed to judge compatibility/incompatibility of intravenous drugs. The purpose of this study was to establish and evaluate a test program of methods suitable for detection of physical incompatibility in Y-site administration of total parenteral nutrition (TPN) and drugs.
methodsEight frequently used methods (dynamic light scattering, laser diffraction, light obscuration, turbidimetry, zeta potential, light microscopy, pH-measurements and visual examination using Tyndall beams), were scrutinized to elucidate strengths and weaknesses for compatibility testing. The responses of the methods were tested with samples containing precipitation of calcium phosphate and with heat destabilized TPN emulsions. A selection of drugs (acyclovir, ampicillin, ondansetron and paracetamol) was mixed with 3-in-1 TPN admixtures (Olimel® N5E, Kabiven® and SmofKabiven®) to assess compatibility (i.e. potential precipitates and emulsion stability). The obtained compatibility data was interpreted according to theory and compared to existing compatibility literature to further check the validity of the methods.
resultsLight obscuration together with turbidimetry, visual inspection and pH-measurements were able to capture signs of precipitations. For the analysis of emulsion stability, light obscuration and estimation of percent droplets above 5 μm (PFAT5) seemed to be the most sensitive method; however laser diffraction and monitoring changes in pH might be a useful support. Samples should always be compared to unmixed controls to reveal changes induced by the mixing. General acceptance criteria are difficult to define, although some limits are suggested based on current experience. The experimental compatibility data was supported by scattered reports in literature, further confirming the suitability of the test program. However, conflicting data are common, which complicates the comparison to existing literature.
conclusionsTesting of these complex blends should be based on a combination of several methods and accompanied by theoretical considerations.
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Registered trials
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