Evidence map›Paper›PMID 26999399›Full record

ReviewMicrobiology spectrum2016

Evolution of Bacterial Pathogens Within the Human Host.

Kimberly A Bliven, Anthony T Maurelli

Open access · greenAbstract readReview
In one paragraph

Review in Microbiology spectrum, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
27.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 202 citations in OpenAlex.

  1. AI-Enabled Imaging for Pathogen Detection Under Stress Conditions: A Systematic Review.Comprehensive reviews in food science and food safety · 2026
    Pooled it
  2. Trial
  3. TheJornal brasileiro de doencas sexualmente transmissiveis : DST · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Functional analysis of cyclic diguanylate-modulating proteins inbioRxiv : the preprint server for biology · 2024
    Article
  8. Evolution of a Pathogenic Microbiome.Journal of clinical medicine · 2023
    Review
  9. Identification and Evaluation of Pathogenic Genes (Reports of biochemistry & molecular biology · 2023
    Article
  10. Molecular Mechanisms ofInternational journal of molecular sciences · 2023
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kimberly A BlivenDepartment of Microbiology and Immunology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814.
Anthony T MaurelliDepartment of Microbiology and Immunology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814.
Uniformed Services University of the Health Sciences · US

Funding

MOLECULAR GENETIC ANALYSIS OF CHLAMYDIA PATHOGENICITYR01AI044033 · NIAID · UNIVERSITY OF FLORIDA · PI MAURELLI, ANTHONY T · 1999 to 2016
$3.9M
TEMPERATURE REGULATION OF SHIGELLA VIRULENCE GENESR01AI024656 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI MAURELLI, ANTHONY T · 1989 to 2013
$3.8M
NIAID NIH HHS R01 AI024656NIAID NIH HHS R01 AI024656-23NIAID NIH HHS R01 AI044033NIAID NIH HHS R01 AI044033-12
6 · The paper itself

Abstract

Selective pressures within the human host, including interactions with innate and adaptive immune responses, exposure to medical interventions such as antibiotics, and competition with commensal microbiota all facilitate the evolution of bacterial pathogens. In this chapter, we present examples of pathogen strategies that emerged as a result of selective pressures within the human host niche and discuss the resulting coevolutionary "arms race" between these organisms. In bacterial pathogens, many of the genes responsible for these strategies are encoded on mobile pathogenicity islands or plasmids, underscoring the importance of horizontal gene transfer in the emergence of virulent microbial species.

Indexed as

BacteriaBiological EvolutionAdaptation, PhysiologicalAnimalsBacterial InfectionsBacterial Physiological PhenomenaHumansSelection, Genetic

Identifiers

PMID26999399
PMCPMC4804625
OpenAlexW2332236125

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.