ArticleThe journal of nutrition, health & aging2016
Impact of Age-related Comorbidities on Five-year Overall Mortality among Elderly HIV-Infected Patients in the Late HAART Era--Role of Chronic Renal Disease.
Article in The journal of nutrition, health & aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Correlates of Poor Quality of Life Among Older People Living With HIV: A Cross-Sectional Analysis of the Tanzania HIV and Aging Cohort Study.Journal of the International AIDS Society · 2026Article
- Calibration and discrimination ability of the Dat'AIDS score in people living with HIV aged 70 years and older from the Dat'AIDS cohort.HIV medicine · 2026Article
- Improving the care pathway for people living with HIV aged 70 years and older: the impact of geriatric screening in an infectious diseases unit (AUTO-HIV 70).BMC geriatrics · 2025Article
- Experiences of Older People Living with Human Immunodeficiency Virus Comorbidity Attending Coordinated Healthcare Services.Annals of geriatric medicine and research · 2025Article
- Disproportionate Vulnerability to and Unique Aggregation Pattern of Non-AIDS Comorbidities Among Women With HIV in China.Open forum infectious diseases · 2025Article
- Survival and mortality profile among people living with HIV in a cohort in the Northeastern region of Brazil.Revista do Instituto de Medicina Tropical de Sao Paulo · 2024Article
- Prevalence and risk factors for kidney disease among hospitalized PLWH in China.AIDS research and therapy · 2023Article
- Article
- Clinical profile, outcomes and predictors of mortality in elderly patients admitted to the emergency medicine intensive care unit of a teaching hospital - A single-center registry.Journal of family medicine and primary care · 2021Article
- Development of type 2 diabetes and insulin resistance in people with HIV infection: Prevalence, incidence and associated factors.PloS one · 2021Article
- Research priorities for accelerating the achievement of three 95 HIV goals in Cameroon: a consensus statement from the Cameroon HIV Research Forum (CAM-HERO).The Pan African medical journal · 2021Article
- Characteristics and outcomes of older people on antiretroviral therapy in Tlokwe Clinics, South Africa.Southern African journal of HIV medicine · 2020Article
- The Journal of Cachexia, Sarcopenia and Muscle stays the front-runner in geriatrics and gerontology.Journal of cachexia, sarcopenia and muscle · 2019Article
- Non-HIV Comorbid Conditions and Polypharmacy Among People Living with HIV Age 65 or Older Compared with HIV-Negative Individuals Age 65 or Older in the United States: A Retrospective Claims-Based Analysis.AIDS patient care and STDs · 2019Article
- Observational
- Trends and predictors of non-communicable disease multimorbidity among adults living with HIV and receiving antiretroviral therapy in Brazil.Journal of the International AIDS Society · 2019Article
- Ageing in patients with chronic HIV infection: impact of hypercoagulation.AIDS research and therapy · 2018Review
- Derivation and internal validation of a mortality risk index for aged people living with HIV: The Dat'AIDS score.PloS one · 2018Article
- Antiretroviral exposure and comorbidities in an aging HIV-infected population: The challenge of geriatric patients.PloS one · 2018Article
- Observational
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11 authors.
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Abstract
objectivesTo identify main prognostic factors for 5-year mortality among age-related comorbidities (ARCs) in older people living with HIV (PLHIV).
designA prospective, multicentre cohort study with a 5-year follow-up period in the late HAART era (from January 2008 to December 2012).
settingThe Dat'AIDS cohort involving 12 French hospitals.
participantsAll actively followed HIV-1 infected patients aged 60 or older. MEASUREMENTS: The study endpoint was all-cause five-year mortality. The following ARCs were considered: chronic renal disease, cardiovascular diseases, cancer, chronic pulmonary disease, cirrhosis, diabetes and nutritional status. Hepatitis C (HCV), hepatitis B (HBV) co-infection and sociodemographic characteristics were also evaluated. Cox's Proportional Hazards model was used for multivariate analysis.
resultsAmong 1415 PLHIV aged 60 or more patients included, mean age was 66±5.5 years; 154 died (mortality rate 2.47/100 patient-years). The most prevalent ARCs were chronic renal disease (20.1%), diabetes (14.2%) and cardiovascular diseases (12.2%). By multivariate analysis, chronic renal disease (adjusted hazard ratio (aHR)=2.25; 95% confidence interval (CI) [1.58-2.21]; p<10-4), cardiovascular diseases (aHR=2.40; 95%CI[1.64-3.52]; p<10-4), non-HIV related cancer (aHR=1.91; 95%CI[1.20-3.05]; p=0.007), cirrhosis (aHR=2.99; 95%CI[1.68-5.33]; p<10-3), HCV co-infection (aHR=2.00; 95%CI[1.18-3.38]; p=0.009), low body mass index (aHR=2.42; 95%CI[1.46-4.01]; p<10-3) and CD4 cell count < 200 cells/µl (aHR=2.23; 95%CI[1.36-3.65]; p=0.002) were independently associated with 5 year mortality.
conclusionDue to a high prevalence, chronic renal disease and cardiovascular disease are main prognostic factors for 5-year mortality among aged PLHIV.
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