ArticleBiosensors2016
Sensing of Salivary Glucose Using Nano-Structured Biosensors.
Article in Biosensors, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 62 citations in OpenAlex.
- An On-Chip Disposable Salivary Glucose Sensor for Diabetes Control.Journal of diabetes science and technology · 2016Trial
- Combined Use of Microwave Sensing Technologies and Artificial Intelligence for Biomedical Monitoring and Imaging.Biosensors · 2026Review
- Review
- Filtered Saliva for Rapid and Accurate Analyte Detection for POC Diagnostics.Diagnostics (Basel, Switzerland) · 2024Article
- A New Model of Salivary Pacemaker-A Proof of Concept and First Clinical Use.Medicina (Kaunas, Lithuania) · 2023Article
- Nanosensors for Visual Detection of Glucose in Biofluids: Are We Ready for Instrument-Free Home-Testing?Materials (Basel, Switzerland) · 2021Review
- Survey of Saliva Components and Virus Sensors for Prevention of COVID-19 and Infectious Diseases.Biosensors · 2020Review
- Salivary Exosomes as Nanocarriers for Cancer Biomarker Delivery.Materials (Basel, Switzerland) · 2019Review
- In Vitro and In Vivo SERS Biosensing for Disease Diagnosis.Biosensors · 2018Review
- Naked-Eye Detection of Glucose in Saliva with Bienzymatic Paper-Based Sensor.Sensors (Basel, Switzerland) · 2018Article
- Electrospun CuO-Nanoparticles-Modified Polycaprolactone @Polypyrrole Fibers: An Application to Sensing Glucose in Saliva.Nanomaterials (Basel, Switzerland) · 2018Article
- Advancing Point-of-Care (PoC) Testing Using Human Saliva as Liquid Biopsy.Diagnostics (Basel, Switzerland) · 2017Review
- An Optical Sensor with Polyaniline-Gold Hybrid Nanostructures for Monitoring pH in Saliva.Nanomaterials (Basel, Switzerland) · 2017Article
- Glucose monitoring system using nanopellets.IET nanobiotechnology · 2017Article
- Development and preliminary evaluation of tongue cleaner-based pH and glucose biosensors for salivary assessment.Journal of oral biology and craniofacial researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The anxiety and pain associated with frequent finger pricking has always been troublesome for diabetics measuring blood glucose (BG) in their daily lives. For this reason, a reliable glucose monitoring system that allows noninvasive measurements is highly desirable. Our main objective is to develop a biosensor that can detect low-level glucose in saliva (physiological range 0.5-20 mg/dL). Salivary glucose (SG) sensors were built using a layer-by-layer self-assembly of single-walled carbon nanotubes, chitosan, gold nanoparticles, and glucose oxidase onto a screen-printed platinum electrode. An electrochemical method was utilized for the quantitative detection of glucose in both buffer solution and saliva samples. A standard spectrophotometric technique was used as a reference method to validate the glucose content of each sample. The disposable glucose sensors have a detection limit of 0.41 mg/dL, a sensitivity of 0.24 μA·s·dL·mg(-1), a linear range of 0.5-20 mg/dL in buffer solution, and a response time of 30 s. A study of 10 healthy subjects was conducted, and SG levels between 1.1 to 10.1 mg/dL were successfully detected. The results revealed that the noninvasive SG monitoring could be an alternative for diabetes self-management at home. This paper is not intended to replace regular BG tests, but to study SG itself as an indicator for the quality of diabetes care. It can potentially help patients control and monitor their health conditions, enabling them to comply with prescribed treatments for diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.