Evidence map›Paper›PMID 26999218›Full record

ReviewPathogens (Basel, Switzerland)2016

Adhesive Pili in UTI Pathogenesis and Drug Development.

Caitlin N Spaulding, Scott J Hultgren

Open access · goldAbstract readReview
In one paragraph

Review in Pathogens (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Whole-proteome structure/function prediction in UropathogenicbioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Review
  9. CAUTIon - not all UTIs are the same.Nature reviews. Urology · 2025
    Review
  10. Article
  11. Mechanisms of uropathogenicScience advances · 2025
    Article
  12. Article
  13. The Role of Metabolomics and Microbiology in Urinary Tract Infection.International journal of molecular sciences · 2024
    Review
  14. Article
  15. Urinary Tract Infections Caused by UropathogenicInternational journal of molecular sciences · 2023
    Review
  16. Article
  17. Article
  18. Review
  19. The Diversity ofMicroorganisms · 2023
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Caitlin N SpauldingDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA. cspaulding@wustl.edu.
Scott J HultgrenDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA. hultgren@wusm.wustl.edu.
Washington University in St. Louis · US

Funding

pan-Genome of E.coli in the bladder and gut of women with recurrent UTIP50DK064540 · NIDDK · WASHINGTON UNIVERSITY · PI HULTGREN, SCOTT J. · 2002 to 2017
$17.9M
Mucosal Immune Defense Mechanisms of the Urinary BladderU01AI095542 · NIAID · WASHINGTON UNIVERSITY · PI COLONNA, MARCO, HULTGREN, SCOTT J. · 2011 to 2020
$9.8M
MOLECULAR BASIS OF E. COLI ADHESINS IN BLADDER DISORDERSR01DK051406 · NIDDK · WASHINGTON UNIVERSITY · PI SCOTT J. HULTGREN · 1997 to 2026
$8.8M
PATHOGENIC FIBER FORMATION IN BACTERIA: STRUCTURAL BASISR01AI048689 · NIAID · WASHINGTON UNIVERSITY · PI HULTGREN, SCOTT J. · 2001 to 2020
$7.6M
CHAPERONE-ASSISTED PILI ASSEMBLY IN PATHOGENIC E. COLIR01AI029549 · NIAID · WASHINGTON UNIVERSITY · PI HULTGREN, SCOTT J., YUAN, PENG · 1991 to 2023
$5.7M
Structure of Proteins Involved in Bacterial PathogenesisR01AI049950 · NIAID · WASHINGTON UNIVERSITY · PI HULTGREN, SCOTT J. · 2001 to 2011
$3.4M
CHAPERONE ASSISTED PILI ASSEMBLY IN PATHOGENIC E COLIR37AI029549 · NIAID · WASHINGTON UNIVERSITY · PI HULTGREN, SCOTT J. · 1999 to 2008
$3.2M
Pathogenic Fiber Formation in Bacteria: Structural BasisR37AI048689 · NIAID · WASHINGTON UNIVERSITY · PI SCOTT J. HULTGREN · 2021 to 2026
$2.9M
NIAID NIH HHS R01 AI029549NIAID NIH HHS R01 AI048689NIAID NIH HHS R01 AI049950NIAID NIH HHS R37 AI029549NIAID NIH HHS R37 AI048689NIAID NIH HHS U01 AI095542NIDDK NIH HHS P50 DK064540NIDDK NIH HHS R01 DK051406
6 · The paper itself

Abstract

Urinary tract infections (UTIs) are one of the most common bacterial infections, affecting 150 million people each year worldwide. High recurrence rates and increasing antimicrobial resistance among uropathogens are making it imperative to develop alternative strategies for the treatment and prevention of this common infection. In this Review, we discuss how understanding the: (i) molecular and biophysical basis of host-pathogen interactions; (ii) consequences of the molecular cross-talk at the host pathogen interface in terms of disease progression; and (iii) pathophysiology of UTIs is leading to efforts to translate this knowledge into novel therapeutics to treat and prevent these infections.

Indexed as

antibiotic-resistanceCAUTIchaperone-usher pathway (CUP) piliEnterococcuspilirUTIUPECUTIvaccine

Identifiers

PMID26999218
PMCPMC4810151
OpenAlexW2302010035

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.