ArticleToxins2016
Characterization of Enzymatic Activity of MlrB and MlrC Proteins Involved in Bacterial Degradation of Cyanotoxins Microcystins.
Article in Toxins, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 44 citations in OpenAlex.
- Three decades of microcystin-LR removal in aquatic environments: physical, chemical and biological strategies for environmental detoxification.Royal Society open science · 2026Article
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- Autoinducer-2 promotes microbial degradation of microcystin-LR by Leuconostoc mesenteroides BSH-02.Archives of microbiology · 2024Article
- Enzymatic mechanism of MlrB for catalyzing linearized microcystins byFrontiers in microbiology · 2024Article
- Purification and Activity of the Second Recombinant Enzyme for Biodegrading Linearized Microcystins byToxins · 2023Article
- Structural insight into the substrate-binding mode and catalytic mechanism for MlrC enzyme ofFrontiers in microbiology · 2023Article
- Purification and Mechanism of Microcystinase MlrC for Catalyzing Linearized Cyanobacterial Hepatotoxins UsingToxins · 2022Article
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- Article
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- Characterization and Mechanism of Linearized-Microcystinase Involved in Bacterial Degradation of Microcystins.Frontiers in microbiology · 2021Article
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- Insight Into the Molecular Mechanisms for Microcystin Biodegradation in Lake Erie and Lake Taihu.Frontiers in microbiology · 2019Article
- Microcystin-LR Degradation and Gene Regulation of Microcystin-DegradingFrontiers in microbiology · 2019Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial degradation of toxic microcystins produced by cyanobacteria is a common phenomenon. However, our understanding of the mechanisms of these processes is rudimentary. In this paper several novel discoveries regarding the action of the enzymes of the mlr cluster responsible for microcystin biodegradation are presented using recombinant proteins. In particular, the predicted active sites of the recombinant MlrB and MlrC were analyzed using functional enzymes and their inactive muteins. A new degradation intermediate, a hexapeptide derived from linearized microcystins by MlrC, was discovered. Furthermore, the involvement of MlrA and MlrB in further degradation of the hexapeptides was confirmed and a corrected biochemical pathway of microcystin biodegradation has been proposed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.