ArticleInternational journal of environmental research and public health2016
Dose-Response Relationship between Cumulative Occupational Lead Exposure and the Associated Health Damages: A 20-Year Cohort Study of a Smelter in China.
Article in International journal of environmental research and public health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- The relationship between air lead and blood lead in a modern US lead-acid battery facility: a longitudinal study.Journal of occupational health · 2024Article
- Characterisation of Particles Emitted during Laser Cutting of Various Metal Sheets and an Exposure Assessment for the Laser Operators.International journal of environmental research and public health · 2022Article
- Influence of task-based airborne lead exposures on blood lead levels: a case study of informal automobile repair artisans in Nakuru town, Kenya.Environmental geochemistry and health · 2020Article
- Pollution and Perceptions of Lead in Automobile Repair Shops in Dhaka, Bangladesh.Journal of health & pollution · 2019Article
- Latent consequences of early-life lead (Pb) exposure and the future: Addressing the Pb crisis.Neurotoxicology · 2018Article
- Quality of life and influencing factors of coal miners in Xuzhou, China.Journal of thoracic disease · 2018Article
- Blood lead level is associated with non-alcoholic fatty liver disease in the Yangtze River Delta region of China in the context of rapid urbanization.Environmental health : a global access science source · 2017Article
- Editorial: Lead Risk Assessment and Health Effects.International journal of environmental research and public health · 2016Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long-term airborne lead exposure, even below official occupational limits, has been found to cause lead poisoning at higher frequencies than expected, which suggests that China's existing occupational exposure limits should be reexamined. A retrospective cohort study was conducted on 1832 smelting workers from 1988 to 2008 in China. These were individuals who entered the plant and came into continuous contact with lead at work for longer than 3 months. The dose-response relationship between occupational cumulative lead exposure and lead poisoning, abnormal blood lead, urinary lead and erythrocyte zinc protoporphyrin (ZPP) were analyzed and the benchmark dose lower bound confidence limits (BMDLs) were calculated. Statistically significant positive correlations were found between cumulative lead dust and lead fumes exposures and workplace seniority, blood lead, urinary lead and ZPP values. A dose-response relationship was observed between cumulative lead dust or lead fumes exposure and lead poisoning (p < 0.01). The BMDLs of the cumulative occupational lead dust and fumes doses were 0.68 mg-year/m³ and 0.30 mg-year/m³ for lead poisoning, respectively. The BMDLs of workplace airborne lead concentrations associated with lead poisoning were 0.02 mg/m³ and 0.01 mg/m³ for occupational exposure lead dust and lead fume, respectively. In conclusion, BMDLs for airborne lead were lower than occupational exposure limits, suggesting that the occupational lead exposure limits need re-examination and adjustment. Occupational cumulative exposure limits (OCELs) should be established to better prevent occupational lead poisoning.
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