ArticleSensors (Basel, Switzerland)2016
Developing an Efficient and General Strategy for Immobilization of Small Molecules onto Microarrays Using Isocyanate Chemistry.
Article in Sensors (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
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- Characterizing Edible Oils by Oblique-Incidence Reflectivity Difference Combined with Machine Learning Algorithms.Foods (Basel, Switzerland) · 2024Article
- Development of a Multiplex HIV/TB Diagnostic Assay Based on the Microarray Technology.Biosensors · 2023Article
- Detection speed optimization of the OI-RD microscope for ultra-high throughput screening.Biomedical optics express · 2023Article
- Emerging degrader technologies engaging lysosomal pathways.Chemical Society reviews · 2022Review
- CDK inhibitor Palbociclib targets STING to alleviate autoinflammation.EMBO reports · 2022Article
- Suppression of toxicity of the mutant huntingtin protein by its interacting compound, desonide.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The study of antiviral drugs targeting SARS-CoV-2 nucleocapsid and spike proteins through large-scale compound repurposing.Heliyon · 2021Article
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- Highly Sensitive Label-Free Detection of Small Molecules with an Optofluidic Microbubble Resonator.Micromachines · 2018Article
- Fast Focal Point Correction in Prism-Coupled Total Internal Reflection Scanning Imager Using an Electronically Tunable Lens.Sensors (Basel, Switzerland) · 2018Article
- Epigallocatechin-3-gallate enhances ER stress-induced cancer cell apoptosis by directly targeting PARP16 activity.Cell death discovery · 2017Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small-molecule microarray (SMM) is an effective platform for identifying lead compounds from large collections of small molecules in drug discovery, and efficient immobilization of molecular compounds is a pre-requisite for the success of such a platform. On an isocyanate functionalized surface, we studied the dependence of immobilization efficiency on chemical residues on molecular compounds, terminal residues on isocyanate functionalized surface, lengths of spacer molecules, and post-printing treatment conditions, and we identified a set of optimized conditions that enable us to immobilize small molecules with significantly improved efficiencies, particularly for those molecules with carboxylic acid residues that are known to have low isocyanate reactivity. We fabricated microarrays of 3375 bioactive compounds on isocyanate functionalized glass slides under these optimized conditions and confirmed that immobilization percentage is over 73%.
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