ArticleMolecules (Basel, Switzerland)2016
Production of Fusaric Acid by Fusarium spp. in Pure Culture and in Solid Medium Co-Cultures.
Article in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Multifunctional biological roles of Fusaric acid and its derivatives in the Diverse Kingdoms of Life: Insights from More Than Nine Decades of Research.Pharmaceutical research · 2026Review
- Genome reshaping by Helitron transposons in Fusarium oxysporum TR4 affects secondary metabolism but not virulence.Nature communications · 2026Article
- Biosynthesis Regulation of Secondary Metabolite Production inJournal of fungi (Basel, Switzerland) · 2025Review
- Targeting microRNA methylation: Innovative approaches to diagnosing and treating hepatocellular carcinoma.Non-coding RNA research · 2025Review
- Profiling of bioactive secondary metabolites from Aspergillus niger against a guava wilt pathogen, Fusarium oxysporum f. sp. psidii.Archives of microbiology · 2024Article
- A mass spectrometry-based strategy for investigating volatile molecular interactions in microbial consortia: unveiling aFrontiers in microbiology · 2024Article
- Enhancing chemical and biological diversity by co-cultivation.Frontiers in microbiology · 2023Review
- Genome-Wide Characterization Reveals Variation Potentially Involved in Pathogenicity and Mycotoxins Biosynthesis ofToxins · 2022Article
- Fungal-fungal co-culture: a primer for generating chemical diversity.Natural product reports · 2022Review
- Combination of Pseudo-LC-NMR and HRMS/MS-Based Molecular Networking for the Rapid Identification of Antimicrobial Metabolites FromFrontiers in molecular biosciences · 2021Article
- Study of in vitro interaction between Fusarium verticillioides and Streptomyces sp. using metabolomics.Folia microbiologica · 2020Article
- Genetic Diversity inFrontiers in plant science · 2019Article
- Dynamics of Metabolite Induction in Fungal Co-cultures by Metabolomics at Both Volatile and Non-volatile Levels.Frontiers in microbiology · 2018Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability of fungi isolated from nails of patients suffering from onychomycosis to induce de novo production of bioactive compounds in co-culture was examined. Comparison between the metabolite profiles produced by Sarocladium strictum, by Fusarium oxysporum, and by these two species in co-culture revealed de novo induction of fusaric acid based on HRMS. Structure confirmation of this toxin, using sensitive microflow NMR, required only three 9-cm Petri dishes of fungal culture. A targeted metabolomics study based on UHPLC-HRMS confirmed that the production of fusaric acid was strain-dependent. Furthermore, the detected toxin levels suggested that onychomycosis-associated fungal strains of the F. oxysporum and F. fujikuroi species complexes are much more frequently producing fusaric acid, and in higher amount, than strains of the F. solani species complex. Fusarium strains producing no significant amounts of this compound in pure culture, were shown to de novo produce that compound when grown in co-culture. The role of fusaric acid in fungal virulence and defense is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.