ArticleJournal of the American Chemical Society2016
Isolation and Synthesis of a Bacterially Produced Inhibitor of Rosette Development in Choanoflagellates.
Article in Journal of the American Chemical Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Isolation of sulfonosphingolipids from the rosette-inducing bacteriumRSC advances · 2023Article
- Total Synthesis and Functional Evaluation of IORs, Sulfonolipid-based Inhibitors of Cell Differentiation in Salpingoeca rosetta.Angewandte Chemie (International ed. in English) · 2022Article
- Identification and Biosynthesis of Pro-Inflammatory Sulfonolipids from an Opportunistic PathogenACS chemical biology · 2022Article
- Identification and structure of an extracellular contractile injection system from the marine bacterium Algoriphagus machipongonensis.Nature microbiology · 2022Article
- Structural and Functional Analysis of Bacterial Sulfonosphingolipids and Rosette-Inducing Factor 2 (RIF-2) by Mass Spectrometry-Guided Isolation and Total Synthesis.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Article
- Chemical Exchanges between Multilateral Symbionts.Organic letters · 2021Article
- Role of Chemical Mediators in Aquatic Interactions across the Prokaryote-Eukaryote Boundary.Journal of chemical ecology · 2018Review
- Lessons from simple marine models on the bacterial regulation of eukaryotic development.Current opinion in microbiology · 2018Review
- EroS Enzyme from Aliivibrio fischeri Plays Cupid to Choanoflagellates.Chembiochem : a European journal of chemical biology · 2017Article
- Natural products and morphogenic activity of γ-Proteobacteria associated with the marine hydroid polyp Hydractinia echinata.Bioorganic & medicinal chemistry · 2017Article
- Sulfonolipids as novel metabolite markers of Alistipes and Odoribacter affected by high-fat diets.Scientific reports · 2017Article
- Mating in the Closest Living Relatives of Animals Is Induced by a Bacterial Chondroitinase.Cell · 2017Article
- Origin of animal multicellularity: precursors, causes, consequences-the choanoflagellate/sponge transition, neurogenesis and the Cambrian explosion.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Inner Workings: Tiny organisms could reveal how animals evolved.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Bacterial lipids activate, synergize, and inhibit a developmental switch in choanoflagellates.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The choanoflagellate Salpingoeca rosetta is a microbial marine eukaryote that can switch between unicellular and multicellular states. As one of the closest living relatives of animals, this organism has become a model for understanding how multicellularity evolved in the animal lineage. Previously our laboratories isolated and synthesized a bacterially produced sulfonolipid that induces S. rosetta to form multicellular "rosettes." In this study, we report the identification of a bacterially produced inhibitor of rosettes (IOR-1) as well as the total synthesis of this molecule and all of its stereoisomers. Our results confirm the previously noted specificity and potency of rosette-modulating molecules, expand our understanding of the complex chemical ecology between choanoflagellates and rosette-inducing bacteria, and provide a synthetic probe template for conducting further mechanistic studies on the emergence of multicellularity.
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