ArticleNature genetics2016
Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population.
Article in Nature genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 207 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
207 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Potential role for immune-related genes in autism spectrum disorders: Evidence from genome-wide association meta-analysis of autistic traits.Autism : the international journal of research and practice · 2022Pooled it
- Genome-wide association study of pediatric obsessive-compulsive traits: shared genetic risk between traits and disorder.Translational psychiatry · 2021Pooled it
- Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder.Nature communications · 2021Pooled it
- Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.Nature genetics · 2018Pooled it
- The contribution of rare variants to risk of schizophrenia in individuals with and without intellectual disability.Nature genetics · 2017Pooled it
- Maternal smoking and autism spectrum disorder: meta-analysis with population smoking metrics as moderators.Scientific reports · 2017Pooled it
- Increased Accuracy of Emotion Recognition in Individuals with Autism-Like Traits after Five Days of Magnetic Stimulations.Neural plasticity · 2020Trial
- Neurocognitive Profiles in Parents of Autistic Children and Parents of Children with Anorexia Nervosa.Journal of autism and developmental disorders · 2026Article
- Distinct Temporal Stages of Infant Brain Processing Associate With Early Versus Later Autism Diagnosis.Developmental science · 2026Article
- Maternal genetic liability to autism spectrum disorders and pregnancy outcomes.Archives of women's mental health · 2026Article
- Rationale and Methods for the Prospective Genetic Risk Evaluation and Assessment (PROGRESS) in Autism Center at Columbia University.Pediatric research · 2026Article
- Integrating Ultimate and Proximate Explanations of Neurodivergence: Evolutionary Trade-Offs, Compensation, and Clinical Expression.Evolutionary applications · 2026Article
- Childhood trauma as a mediator between autistic traits and depression: Evidence from the ALSPAC birth cohort.Psychological medicine · 2026Article
- In silico Genotype-Phenotype Correlation Analysis of Inherited Variations in Autism Spectrum Disorder Families Identify an Interplay between Sensory Function and Repetitive-behaviour Genes.Journal of molecular neuroscience : MN · 2026Article
- Subclinical neuropsychiatric trait variation in parents of children with autism spectrum disorder: a cohort study.Molecular autism · 2026Article
- Perinatal exposure to gaseous pollutants and autism spectrum disorder in children: A nested case-control study in the nurses' health study ii cohort.Environmental science and pollution research international · 2026Article
- Article
- Detection of Idiosyncratic Gaze-Fingerprint Signatures in Humans.Psychological science · 2026Article
- Mid-childhood developmental and behavioural outcomes in infants with a family history of autism and/or attention deficit hyperactivity disorder.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Diagnostic inflation in autism spectrum disorder: an epistemological and methodological reappraisal.Frontiers in psychiatry · 2026Review
147 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
23 authors.
Funding
Abstract
Almost all genetic risk factors for autism spectrum disorders (ASDs) can be found in the general population, but the effects of this risk are unclear in people not ascertained for neuropsychiatric symptoms. Using several large ASD consortium and population-based resources (total n > 38,000), we find genome-wide genetic links between ASDs and typical variation in social behavior and adaptive functioning. This finding is evidenced through both LD score correlation and de novo variant analysis, indicating that multiple types of genetic risk for ASDs influence a continuum of behavioral and developmental traits, the severe tail of which can result in diagnosis with an ASD or other neuropsychiatric disorder. A continuum model should inform the design and interpretation of studies of neuropsychiatric disease biology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.