Evidence map›Paper›PMID 26998571›Full record

ArticleDevelopmental psychology2016

Oxytocin and parent-child interaction in the development of empathy among children at risk for autism.

Nicole M McDonald, Jason K Baker, Daniel S Messinger

Abstract read
In one paragraph

Article in Developmental psychology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Empathy in Autism Spectrum Disorder.Journal of autism and developmental disorders · 2019
    Article
  11. Parental criticism and behavior problems in children with autism spectrum disorder.Autism : the international journal of research and practice · 2019
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nicole M McDonaldDepartment of Psychology, University of Miami.
Jason K BakerDepartment of Child and Adolescent Studies, California State University.
Daniel S MessingerDepartment of Psychology, University of Miami.

Funding

Social-Emotional Development of Infants At Risk for Autism SpectrumR01HD057284 · NICHD · VANDERBILT UNIVERSITY · PI MESSINGER, DANIEL S, STONE, WENDY L. · 2008 to 2012
$3.1M
Modeling the Dynamics of Early Communication and DevelopmentR01GM105004 · NIGMS · UNIVERSITY OF MIAMI CORAL GABLES · PI CHOW, SY-MIIN, COHN, JEFFREY F · 2013 to 2016
$2.1M
Emotion, communication, & EEG: Development & riskR01HD047417 · NICHD · UNIVERSITY OF MIAMI CORAL GABLES · PI MESSINGER, DANIEL S · 2006 to 2010
$1.5M
NICHD NIH HHS R01 HD047417NICHD NIH HHS R01 HD057284NIGMS NIH HHS R01 GM105004
6 · The paper itself

Abstract

This longitudinal study investigated whether variation in the oxytocin receptor gene (OXTR) and early parent-child interactions predicted later empathic behavior in 84 toddlers at high or low familial risk for autism spectrum disorder. Two well-studied OXTR single-nucleotide polymorphisms, rs53576 and rs2254298, were examined. Parent-child interaction was measured at 15 and 18 months of age during free play sessions. Empathy was measured at 24 and 30 months using a response to parental distress paradigm. While there was no direct association between parent-child interaction quality or OXTR and empathy, rs53576 moderated the relation between interaction quality and empathy. Results suggest that the interplay between OXTR and early parent-child interactions predicts individual differences in empathy in children at varying risk for atypical social development. Findings are consonant with a differential susceptibility model in which an OXTR variant may increase the social salience of interaction processes for specific allele carriers. These results increase our understanding of predictors of empathy development in young children with a wide range of social outcomes. (PsycINFO Database Record

Indexed as

EmpathyParent-Child RelationsAge FactorsAutism Spectrum DisorderChildChild, PreschoolFemaleGenetic Association StudiesGenotypeHumansLongitudinal StudiesMaleOxytocinPolymorphism, Single NucleotideReceptors, OxytocinRegression AnalysisOxytocinReceptors, Oxytocin

Identifiers

PMID26998571
PMCPMC4844836

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.