ArticleBladder (San Francisco, Calif.)
Sex differences in the MB49 syngeneic, murine model of bladder cancer.
Article in Bladder (San Francisco, Calif.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Reduced Tumor Control in Males Can Result from Impaired CD4+ T-cell Help through the CD40L-CD40 Pathway.Cancer immunology research · 2026Article
- Microbiota-derived bile acids antagonize the host androgen receptor and drive anti-tumor immunity.Cell · 2025Article
- Metabolic Reprogramming of Tumor-Associated Macrophages Using Glutamine Antagonist JHU083 Drives Tumor Immunity in Myeloid-Rich Prostate and Bladder Cancers.Cancer immunology research · 2024Article
- Article
- In Vivo Optical Imaging of Bladder Cancer Tissues in an MB49 Bladder Cancer Orthotopic Mouse Model Using the Intravesical or Intravenous Administration of Near-Infrared Fluorescence Probe.International journal of molecular sciences · 2023Article
- Androgen conspires with the CD8Science immunology · 2022Article
- MyD88-dependent BCG immunotherapy reduces tumor and regulates tumor microenvironment in bladder cancer murine model.Scientific reports · 2021Article
- Genome-Wide and Phenotypic Evaluation of Stem Cell Progenitors Derived FromFrontiers in oncology · 2019Article
- Using Visualization ofJournal of immunology (Baltimore, Md. : 1950) · 2017Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe MB49 syngeneic, murine model of bladder cancer has been widely used for more than 35 years. In humans, bladder cancer is one third as prevalent in women as in men, with a trend toward lower prevalence in parous compared to nulliparous women. Our objective was to determine if the MB49 bladder cancer model reproduces the sex differences observed in humans, and to determine its sensitivity to testosterone and the pregnancy hormone, human chorionic gonadotropin (hCG).
methodsMale and female C57BL/6 mice were implanted with MB49 murine bladder cancer cells, and observed for tumor growth. MB49 dose responses to hCG and dihydrotestosterone were determined
resultsMB49 tumor growth was significantly greater in male mice than female mice. Pregnancy did not affect MB49 tumor growth in female mice. MB49 cells did not proliferate in response to hCG
conclusionsThe MB49 murine model of bladder cancer reproduced some aspects of the sex differences observed in humans. Our results suggest that testosterone may stimulate MB49 cell proliferation, which may explain the more rapid MB49 tumor growth observed in male mice.
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