Evidence map›Paper›PMID 26998496›Full record

ReviewJournal of immunology research2016

The Toll of Vascular Insufficiency: Implications for the Management of Peripheral Arterial Disease.

Jun Xu, Ulka Sachdev

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of immunology research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Biological and pathophysiological roles of end-products of DHA oxidation.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2017
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jun XuDivision of Vascular Surgery, University of Pittsburgh Medical Center, 200 Lothrop Street, Suite A1011, Pittsburgh, PA 15213, USA.
Ulka SachdevDivision of Vascular Surgery, University of Pittsburgh Medical Center, 200 Lothrop Street, Suite A1011, Pittsburgh, PA 15213, USA.
University of Pittsburgh Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peripheral artery disease (PAD) can result in limb loss within six months of diagnosis in a subset of patients who cannot undergo endovascular or surgical revascularization yet continues to maintain a marginal position in cardiovascular research. While a body of literature continues to grow describing the role of danger signaling and innate immunity in cardiac biology, the role of these pathways in the ischemic myopathy associated with PAD has not been extensively studied. The following report will review the current literature on the role of Toll-like receptor (TLR) signaling in cardiovascular biology as well as in nonischemic myopathy. While attenuation of TLR signaling has not been shown to be clinically useful in the treatment of infectious inflammation, it may show promise in the management of severe arterial insufficiency.

Indexed as

Adaptor Proteins, Vesicular TransportArteriesGene Expression RegulationHumansImmunity, InnateIschemiaMuscular DiseasesMyeloid Differentiation Factor 88Myocytes, CardiacPeripheral Arterial DiseaseSignal TransductionToll-Like ReceptorsAdaptor Proteins, Vesicular TransportMYD88 protein, humanMyeloid Differentiation Factor 88TICAM1 protein, humanToll-Like Receptors

Identifiers

PMID26998496
PMCPMC4779544
OpenAlexW2276494697

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.