Evidence map›Paper›PMID 26998434›Full record

ArticleTropical parasitology

Topographic congruence of calcified parenchymal neurocysticercosis and other structural brain lesions with epileptiform activity.

Erin K Saito, Meera Nagpal, Amanda Leon, Bijal Mehta, Aaron Matthew McMurtray

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tropical parasitology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Erin K SaitoDepartment of Neurology, Division of Neurology, Los Angeles Biomedical Research Institute, Torrance, CA 90502, USA.
Meera NagpalDepartment of Neurology, Division of Neurology, Los Angeles Biomedical Research Institute, Torrance, CA 90502, USA.
Amanda LeonDepartment of Neurology, Division of Neurology, Los Angeles Biomedical Research Institute, Torrance, CA 90502, USA; W. M. Keck Science Center, Pitzer College, Claremont, CA 91711, USA.
Bijal MehtaDepartment of Neurology, Division of Neurology, Los Angeles Biomedical Research Institute, Torrance, CA 90502, USA; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA; Department of Neurology, Harbor-UCLA Medical Center, Torrance, CA 90509, USA.
Aaron Matthew McMurtrayDepartment of Neurology, Division of Neurology, Los Angeles Biomedical Research Institute, Torrance, CA 90502, USA; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA; Department of Neurology, Harbor-UCLA Medical Center, Torrance, CA 90509, USA.
The Lundquist Institute · USPitzer College · USUCLA Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCalcified parenchymal neurocysticercosis (NCC) lesions are commonly detected in many individuals with refractory epilepsy. However, the relationship between these lesions and epilepsy is not fully determined. We sought to determine if calcified parenchymal NCC demonstrated topographic congruence with epileptiform activity in refractory epilepsy patients. Additional patients with other structural brain lesions were included for comparison. SUBJECTS AND

methodsRetrospective cross-sectional analysis of all patients treated at a community-based neurology clinic for refractory epilepsy during a 3-month period and with structural brain lesions detected by neuroimaging studies.

resultsA total of 105 patients were included in the study, including 63 with calcified parenchymal NCC lesions and 42 with other structural brain lesions. No significant relationship was detected between hemispheric localization of calcified parenchymal NCC lesions and epileptiform activity. For those with other structural brain lesions, the hemispheric localization was significantly related to the side of epileptiform activity (Chi-square = 11.13, P = 0.025). In addition, logistic regression models showed that those with right-sided non-NCC lesions were more likely to have right-sided epileptiform activity (odds ratio = 4.36, 95% confidence interval [CI] =1.16-16.31, P = 0.029), and those with left-sided non-NCC lesions were more likely to have left-sided epileptiform activity (odds ratio = 7.60, 95% CI = 1.89-30.49, P = 0.004).

conclusionThe lack of correlation between the side of calcified parenchymal NCC lesions and the side of the epileptiform activity suggests that these lesions may be incidental findings in many patients.

Indexed as

Epilepsyetiologyneurocysticercosis

Identifiers

PMID26998434
PMCPMC4778183
OpenAlexW2394797363

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.