Evidence map›Paper›PMID 26998358›Full record

ArticleInternational journal of medicinal chemistry2016

Design and Microwave Assisted Synthesis of Coumarin Derivatives as PDE Inhibitors.

Mahadev N Kumbar, Ravindra R Kamble, Atulkumar A Kamble, Sujith Raj Salian, Sandhya Kumari, Ramya Nair, Guruprasad Kalthur, Satish Kumar Adiga, D Jagadeesh Prasad

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In one paragraph

Article in International journal of medicinal chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mahadev N KumbarDepartment of Chemistry, Karnatak University, Pavate Nagar, Dharwad 580003, India.
Ravindra R KambleDepartment of Chemistry, Karnatak University, Pavate Nagar, Dharwad 580003, India.
Atulkumar A KambleDepartment of Chemistry, Karnatak University, Pavate Nagar, Dharwad 580003, India.
Sujith Raj SalianCentre of Excellence in Clinical Embryology, Level 2, Central Research Lab, Kasturba Medical College, Manipal University, Manipal, Karnataka 576104, India.
Sandhya KumariCentre of Excellence in Clinical Embryology, Level 2, Central Research Lab, Kasturba Medical College, Manipal University, Manipal, Karnataka 576104, India.
Ramya NairCentre of Excellence in Clinical Embryology, Level 2, Central Research Lab, Kasturba Medical College, Manipal University, Manipal, Karnataka 576104, India.
Guruprasad KalthurCentre of Excellence in Clinical Embryology, Level 2, Central Research Lab, Kasturba Medical College, Manipal University, Manipal, Karnataka 576104, India.
Satish Kumar AdigaCentre of Excellence in Clinical Embryology, Level 2, Central Research Lab, Kasturba Medical College, Manipal University, Manipal, Karnataka 576104, India.
D Jagadeesh PrasadDepartment of Studies in Chemistry, Mangalore University, Konaje, Karnataka 574199, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coumarins appended to benzimidazole through pyrazole are designed and synthesized using microwave irradiation. These compounds were analyzed for phosphodiesterase (PDE) inhibition indirectly by motility pattern in human spermatozoa. Some of the synthesized compounds, namely, 5d, 5e, 5f, 5g, 5h, and 5k, have exhibited potent inhibitory activity on PDE.

Identifiers

PMID26998358
PMCPMC4779523

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.