Evidence map›Paper›PMID 26998252›Full record

ArticleRSC advances2016

Self-Assembled Nanospheres for Encapsulation and Aerosolization of Rifampicin.

Aline A Ishikawa, Jesus V Salazar, Magaly Salinas, Cristiane M Gaitani, Timothy Nurkiewicz, George R Negrete, Carlos D Garcia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aline A IshikawaSchool of Pharmaceutical Sciences of Ribeirão Preto, Ribeirao Preto, SP, Brazil; Department of Chemistry, Clemson University, Clemson, SC 29634, USA.
Jesus V SalazarDepartment of Physics and Astronomy, UT San Antonio, San Antonio, TX, USA.
Magaly SalinasDepartment of Chemistry, UT San Antonio, San Antonio, TX, USA.
Cristiane M GaitaniSchool of Pharmaceutical Sciences of Ribeirão Preto, Ribeirao Preto, SP, Brazil.
Timothy NurkiewiczDepartment of Physiology & Pharmacology, Center for Cardiovascular & Respiratory Sciences, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV, USA.
George R NegreteDepartment of Chemistry, UT San Antonio, San Antonio, TX, USA.
Carlos D GarciaDepartment of Chemistry, Clemson University, Clemson, SC 29634, USA.

Funding

RCMI Center for Interdiscplinary Health Research CIHRG12MD007591 · NIMHD · UNIVERSITY OF TEXAS SAN ANTONIO · PI PERRY, GEORGE · 2012 to 2016
$10.4M
Remote Microvascular Dysfunction After Particulate Matter ExposureR01ES015022 · NIEHS · WEST VIRGINIA UNIVERSITY · PI NURKIEWICZ, TIMOTHY R · 2007 to 2021
$4.9M
NIEHS NIH HHS R01 ES015022NIMHD NIH HHS G12 MD007591
6 · The paper itself

Abstract

Rifampicin (RIF) is a benchmark drug for treatment of tuberculosis, but poor bioavailability, prolonged treatment, and pill burden have been linked to therapeutic failure and the development of multidrug resistant strains. To overcome these limitations, this study investigated a method of rifampicin nanoencapsulation and aerosol delivery using a commercial, hand-held nebulizer modified with a nitrogen stream.

Identifiers

PMID26998252
PMCPMC4792303

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.