Evidence map›Paper›PMID 26997983›Full record

ArticleExperimental and therapeutic medicine2016

Curcumin alleviates brain edema by lowering AQP4 expression levels in a rat model of hypoxia-hypercapnia-induced brain damage.

Lin-Sheng Yu, Yan-Yan Fan, Guanghua Ye, Junli Li, Xiang-Ping Feng, Kezhi Lin, Miuwu Dong, Zhenyuan Wang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental and therapeutic medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Aquaporins in Nervous System.Advances in experimental medicine and biology · 2023
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Aquaporins as Targets of Dietary Bioactive Phytocompounds.Frontiers in molecular biosciences · 2018
    Review
  17. Review
  18. Article
  19. Experimental and therapeutic medicine · 2017
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Lin-Sheng YuShanghai Key Lab of Forensic Medicine, Shanghai City West, Shanghai 200063, P.R. China; Xi'an Jiaotong University Health Science Center, School of Forensic Science and Medicine, Xi'an, Shaanxi 710061, P.R. China; Department of Forensic Medicine, Wenzhou Medical University, Wenzhou, Zhejiang 325035w; Institute of Forensic Science, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
Yan-Yan FanDepartment of Forensic Medicine, Wenzhou Medical University, Wenzhou, Zhejiang 325035w; Institute of Forensic Science, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
Guanghua YeDepartment of Forensic Medicine, Wenzhou Medical University, Wenzhou, Zhejiang 325035w; Institute of Forensic Science, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
Junli LiDepartment of Forensic Medicine, Wenzhou Medical University, Wenzhou, Zhejiang 325035w; Institute of Forensic Science, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
Xiang-Ping FengDepartment of Forensic Medicine, Wenzhou Medical University, Wenzhou, Zhejiang 325035w; Institute of Forensic Science, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
Kezhi LinDepartment of Forensic Medicine, Wenzhou Medical University, Wenzhou, Zhejiang 325035w; Institute of Forensic Science, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
Miuwu DongDepartment of Forensic Medicine, Wenzhou Medical University, Wenzhou, Zhejiang 325035w; Institute of Forensic Science, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
Zhenyuan WangShanghai Key Lab of Forensic Medicine, Shanghai City West, Shanghai 200063, P.R. China; Xi'an Jiaotong University Health Science Center, School of Forensic Science and Medicine, Xi'an, Shaanxi 710061, P.R. China.
Wenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study aimed to investigate the therapeutic effects of curcumin (CU) against brain edema in a rat model of hypoxia-hypercapnia (HH)-induced brain damage (HHBD). Male Sprague-Dawley rats were divided into five groups, including a control group and four treatment groups. The rats in the control group were raised under normal laboratory conditions and were injected with water, whereas the rats in the treatment groups were exposed to a low O

Indexed as

aquaporin-4brain edemachronic hypoxia-hypercapnia-induced brain damagecurcumin

Identifiers

PMID26997983
PMCPMC4774356
OpenAlexW2252888305

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.