ArticleClinical medicine insights. Case reports2016
Tubulointerstitial Nephritis and Uveitis Syndrome: Are Drugs Offenders or Bystanders?
Article in Clinical medicine insights. Case reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Tubulointerstitial nephritis and uveitis (TINU) syndrome: a systematic review of its epidemiology, demographics and risk factors.Orphanet journal of rare diseases · 2017Pooled it
- Review of adverse events associated with COVID-19 vaccines, highlighting their frequencies and reported cases.Journal of Taibah University Medical Sciences · 2023Review
- Article
- Usefulness of renal diffusion-weighted magnetic resonance imaging for early diagnosis of tubulointerstitial nephritis and uveitis (TINU) syndrome.BMJ case reports · 2022Article
- A Case of Acute Interstitial Nephritis After Two Doses of the BNT162b2 SARS-CoV-2 Vaccine.International journal of nephrology and renovascular disease · 2021Article
- Article
- A child with tubulointerstitial nephritis and uveitis (TINU) syndrome.BMJ case reports · 2018Article
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Authors and funding
10 authors.
Funding
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Abstract
A 16-year-old female patient was admitted to our hospital due to progressive renal dysfunction with an increased serum creatinine (sCr) level of 1.7 mg/dL. Her clinical course without any ocular manifestations and results of drug-induced, lymphocyte-stimulating tests, in addition to a renal histological assessment, initially encouraged us to ascribe the patient's renal abnormalities to drug-induced acute interstitial nephritis (AIN). Four months later, she started to complain about reduced visual acuity when she was found to have anterior bilateral uveitis despite the recovered renal function with almost constant sCr levels around 0.7 mg/dL. Thus, a diagnosis of tubulointerstitial nephritis and uveitis (TINU) syndrome was finally made. Our case illustrates the difficulties in distinguishing late-onset uveitis TINU syndrome from drug-induced AIN at the time of the renal biopsy, thereby suggesting the importance of a longitudinal follow-up to overcome the potential underdiagnosis of the disease. Several diagnostic conundrums that emerged in this case are also discussed.
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