ArticleArchives of virology2016
In vitro antiviral effect of germacrone on feline calicivirus.
Article in Archives of virology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- The Antiviral Potential ofMolecules (Basel, Switzerland) · 2024Pooled it
- Nanoparticle Delivery Systems in Rheumatoid Arthritis: More Than Vehicles.Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- Essential oils expose diverse targets on non-enveloped ScV-L-A totivirus.Pharmaceutical biology · 2025Article
- Feline Calicivirus Infection: Current Understanding and Implications for Control Strategies.Animals : an open access journal from MDPI · 2025Review
- Essential Oils: Chemistry and Pharmacological Activities.Biomolecules · 2023Review
- Delivery of germacrone (GER) using macrophages-targeted polymeric nanoparticles and its application in rheumatoid arthritis.Drug delivery · 2022Article
- Progress of Research into Novel Drugs and Potential Drug Targets against Porcine Pseudorabies Virus.Viruses · 2022Review
- Nitazoxanide protects cats from feline calicivirus infection and acts synergistically with mizoribine in vitro.Antiviral research · 2020Article
- Antiviral effect of copper chloride on feline calicivirus and synergy with ribavirin in vitro.BMC veterinary research · 2020Article
- Antiviral Effects of Plant-Derived Essential Oils and Their Components: An Updated Review.Molecules (Basel, Switzerland) · 2020Review
- Antiviral Activity of Germacrone against Pseudorabies Virus in Vitro.Pathogens (Basel, Switzerland) · 2019Article
- Equine immunoglobulin F(ab')International immunopharmacology · 2019Article
- Article
- Identification of Feline Interferon Regulatory Factor 1 as an Efficient Antiviral Factor against the Replication of Feline Calicivirus and Other Feline Viruses.BioMed research international · 2018Article
- Identification of Inonotus obliquus polysaccharide with broad-spectrum antiviral activity against multi-feline viruses.International journal of biological macromolecules · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Feline calicivirus (FCV) often causes respiratory tract and oral disease in cats and is a highly contagious virus. Widespread vaccination does not prevent the spread of FCV. Furthermore, the low fidelity of the RNA-dependent RNA polymerase of FCV leads to the emergence of new variants, some of which show increased virulence. Currently, few effective anti-FCV drugs are available. Here, we found that germacrone, one of the main constituents of volatile oil from rhizoma curcuma, was able to effectively reduce the growth of FCV strain F9 in vitro. This compound exhibited a strong anti-FCV effect mainly in the early phase of the viral life cycle. The antiviral effect depended on the concentration of the drug. In addition, germacrone treatment had a significant inhibitory effect against two other reference strains, 2280 and Bolin, and resulted in a significant reduction in the replication of strains WZ-1 and HRB-SS, which were recently isolated in China. This is the first report of antiviral effects of germacrone against a calicivirus, and extensive in vivo research is needed to evaluate this drug as an antiviral therapeutic agent for FCV.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.