ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2016
Novel Primate Model of Serotonin Transporter Genetic Polymorphisms Associated with Gene Expression, Anxiety and Sensitivity to Antidepressants.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Genetic variants of SLC6A4 and risk of coronary artery disease: insights from North Indian population.Orphanet journal of rare diseases · 2025Article
- Evolution of threat response-related polymorphisms at theBiology letters · 2024Article
- Use of hormonal contraceptives and antidepressants and risks of suicidal behavior and accidents among women with premenstrual disorders: a nationwide cohort study.BMC medicine · 2022Article
- Higher-order brain regions show shifts in structural covariance in adolescent marmosets.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Resting-State fMRI-Based Screening of Deschloroclozapine in Rhesus Macaques Predicts Dosage-Dependent Behavioral Effects.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Understanding them to understand ourselves: The importance of NHP research for translational neuroscience.Current research in neurobiology · 2022Article
- Quantifying anhedonia-like symptoms in marmosets using appetitive Pavlovian conditioning.STAR protocols · 2021Article
- Common HTR2A variants and 5-HTTLPR are not associated with human in vivo serotonin 2A receptor levels.Human brain mapping · 2020Article
- Trait Anxiety Mediated by Amygdala Serotonin Transporter in the Common Marmoset.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Avoidant Coping Style to High Imminence Threat Is Linked to Higher Anxiety-Like Behavior.Frontiers in behavioral neuroscience · 2020Article
- Insula serotonin 2A receptor binding and gene expression contribute to serotonin transporter polymorphism anxious phenotype in primates.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Serotonin Receptor 1A Variation Is Associated with Anxiety and Agonistic Behavior in Chimpanzees.Molecular biology and evolution · 2019Article
- Glutamate Within the Marmoset Anterior Hippocampus Interacts with Area 25 to Regulate the Behavioral and Cardiovascular Correlates of High-Trait Anxiety.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
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- The role of prefrontal-subcortical circuitry in negative bias in anxiety: Translational, developmental and treatment perspectives.Brain and neuroscience advances · 2018Article
- Article
- A dimensional approach to modeling symptoms of neuropsychiatric disorders in the marmoset monkey.Developmental neurobiology · 2017Review
- The Neurobiology of Panic: A Chronic Stress Disorder.Chronic stress (Thousand Oaks, Calif.)Review
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Genetic polymorphisms in the repeat upstream region of the serotonin transporter gene (SLC6A4) are associated with individual differences in stress reactivity, vulnerability to affective disorders, and response to pharmacotherapy. However, the molecular, neurodevelopmental and psychopharmacological mechanisms underlying the link between SLC6A4 polymorphisms and the emotionally vulnerable phenotype are not fully understood. Thus, using the marmoset monkey Callithrix jacchus we characterize here a new neurobiological model to help to address these questions. We first sequenced the marmoset SLC6A4 promoter and identified a double nucleotide polymorphism (-2053AC/CT) and two single-nucleotide polymorphisms (-2022C/T and -1592G/C) within the repeat upstream region. We showed their association with gene expression using in vivo quantitative PCR and with affective behavior using a primate test of anxiety (human intruder test). The low-expressing haplotype (AC/C/G) was linked with high anxiety while the high-expressing one (CT/T/C) was associated with an active coping strategy in response to threat. Pharmacological challenge with an acute dose of the selective serotonin reuptake inhibitor, citalopram, revealed a genotype-dependent behavioral response. While individuals homozygous for the high anxiety-related haplotype AC/C/G exhibited a dose-dependent, anxiogenic response, individuals homozygous for the low anxiety-related haplotype CT/T/C showed an opposing, dose-dependent anxiolytic effect. These findings provide a novel genetic and behavioral primate model to study the molecular, neurodevelopmental, and psychopharmacological mechanisms that underlie genetic variation-associated complex behaviors, with specific implications for the understanding of normal and abnormal serotonin actions and the development of personalized pharmacological treatments for psychiatric disorders.
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