Evidence map›Paper›PMID 26997283›Full record

ArticleCell reports2016

Distinct Roles of the Prefrontal and Posterior Parietal Cortices in Response Inhibition.

Xin Zhou, Xue-Lian Qi, Christos Constantinidis

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

  1. Trajectories of Response Inhibition Development in Adolescence.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
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  5. Article
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  8. Strong Gamma Frequency Oscillations in the Adolescent Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  9. Article
  10. Article
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  12. Plasticity of Persistent Activity and Its Constraints.Frontiers in neural circuits · 2020
    Review
  13. Article
  14. Review
  15. An Essential Role of the Intraparietal Sulcus in Response Inhibition Predicted by Parcellation-Based Network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Xin ZhouDepartment of Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA; Department of Computer Science, Stanford University, Stanford, CA 94305, USA.
Xue-Lian QiDepartment of Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Christos ConstantinidisDepartment of Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA. Electronic address: cconstan@wakehealth.edu.
Wake Forest University · USStanford University · US

Funding

CORTICAL CIRCUIT BASIS OF VISUAL SPATIAL PROCESSINGR01EY016773 · NEI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CONSTANTINIDIS, CHRISTOS · 2008 to 2017
$2.3M
Neurophysiology of Prefrontal Cortical DevelopmentR33MH086946 · NIMH · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CONSTANTINIDIS, CHRISTOS, STANFORD, TERRENCE R · 2012 to 2013
$711k
NEI NIH HHS R01 EY016773NIMH NIH HHS R33 MH086946NIMH NIH HHS R33MH86946
6 · The paper itself

Abstract

The dorsolateral prefrontal cortex and posterior parietal cortex have been implicated in the planning of movements and inhibition of inappropriate responses, though their precise roles in these functions are not known. To address this question, we trained monkeys to perform memory-guided saccade and anti-saccade tasks and compared neural responses in the same animals. A population of neurons with no motor responses was also activated by a stimulus appearing out of the receptive field and could therefore mediate vector inversion. These neurons were found almost exclusively in the prefrontal cortex. Prefrontal cortical activity better predicted the level of performance in the task. Representation of the saccade goal also peaked in the prefrontal cortex at a time that was predictive of reaction time. These results suggest that the prefrontal cortex is the primary site of vector inversion in the cerebral cortex and explain the importance of this area in response inhibition.

Indexed as

AnimalsArea Under CurveHaplorhiniMaleMemoryParietal LobePhotic StimulationPrefrontal CortexROC CurveSaccades

Identifiers

PMID26997283
PMCPMC4814327
OpenAlexW2299818632

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.