Evidence map›Paper›PMID 26997190›Full record

ArticleJournal of studies on alcohol and drugs2016

Acquisition of Conditioned Responses to a Novel Alcohol-Paired Cue in Social Drinkers.

Leah M Mayo, Harriet de Wit

Open access · bronzeAbstract read
In one paragraph

Article in Journal of studies on alcohol and drugs, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
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  9. Review
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  11. Article
  12. Neural responses to cues paired with methamphetamine in healthy volunteers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018
    Article
  13. Evidence for a Long-Lasting Compulsive Alcohol Seeking Phenotype in Rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Leah M MayoDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois.
Harriet de WitDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois.
Linköping University · SEUniversity of Chicago · US

Funding

Determinants of Drug Preference in Humans--Administrative SupplementR01DA002812 · NIDA · UNIVERSITY OF CHICAGO · PI DE WIT, HARRIET · 1985 to 2024
$10.6M
The genetic basis of impulsive behavior in humansR01DA032015 · NIDA · UNIVERSITY OF CHICAGO · PI DE WIT, HARRIET · 2011 to 2015
$2.4M
Acquisition and persistence of drug cue conditioning in humans - Resubmission 01R01DA037011 · NIDA · UNIVERSITY OF CHICAGO · PI DE WIT, HARRIET · 2014 to 2018
$2.3M
NIDA NIH HHS DA02812NIDA NIH HHS DA32015NIDA NIH HHS R01 DA002812NIDA NIH HHS R01 DA032015NIDA NIH HHS R01 DA037011
6 · The paper itself

Abstract

objectiveThis study examined the acquisition of conditioning between novel stimuli and single doses of alcohol in social drinkers. Environmental stimuli present during the consumption of alcohol or other drugs come to elicit conditioned responses that subsequently increase drug seeking. However, relatively few studies have examined the process of acquisition of these conditioned drug responses in human subjects.

methodWe used a procedure previously developed to study acquisition of conditioned responses to a methamphetamine-associated cue. In the present study we applied the paradigm to alcohol, pairing de novo neutral cues with alcohol in social drinkers (N = 36). We obtained measures of self-report, behavioral preference, emotional reactivity (assessed using facial electromyography), and attention to specific cues paired with administration of 0.6 g/kg 95% absolute alcohol or placebo.

resultsAfter conditioning, participants showed an increase in attention toward the alcohol-paired cue, and this increase was associated with ratings of liking the alcohol-containing beverage during the conditioning sessions. In contrast to our previous findings with methamphetamine, the alcohol-paired cue did not elicit changes in emotional reactivity (measured by facial electromyography) or behavioral preference.

conclusionsThis study extends our previous findings with a stimulant drug to alcohol and highlights possible similarities and differences in conditioning with different classes of drugs. Conditioning with alcohol was less robust than with methamphetamine, but in both cases the conditioning that did occur was related to positive subjective drug response.

Indexed as

Alcoholic BeveragesCuesAdultAlcohol DrinkingAttentionConditioning, PsychologicalDouble-Blind MethodEthanolFemaleHumansMaleMethamphetamineReaction TimeYoung AdultEthanolMethamphetamine

Identifiers

PMID26997190
PMCPMC4803664
OpenAlexW2332629293

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.