Evidence map›Paper›PMID 26997180›Full record

ArticleJournal of studies on alcohol and drugs2016

DISC1 as a Possible Genetic Contribution to Opioid Dependence in a Polish Sample.

Sylwia Fudalej, Andrzej Jakubczyk, Maciej Kopera, Jerzy Piwonski, Wojciech Bielecki, Wojciech Drygas, Krystyna Wasilewska, Mark Ilgen, Amy Bohnert, Kristen Barry and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of studies on alcohol and drugs, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Frontiers in pharmacology · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Sylwia FudalejDepartment of Psychiatry, Medical University of Warsaw, Warsaw, Poland.
Andrzej JakubczykDepartment of Psychiatry, Medical University of Warsaw, Warsaw, Poland.
Maciej KoperaDepartment of Psychiatry, Medical University of Warsaw, Warsaw, Poland.
Jerzy PiwonskiDepartment of Epidemiology, Cardiovascular Disease Prevention, and Health Promotion, National Institute of Cardiology, Warsaw, Poland.
Wojciech BieleckiDepartment of Social Pathologies, Medical University of Lodz, Lodz, Poland.
Wojciech DrygasDepartment of Epidemiology, Cardiovascular Disease Prevention, and Health Promotion, National Institute of Cardiology, Warsaw, Poland.
Krystyna WasilewskaDepartment of Medical Genetics, Medical University of Warsaw, Warsaw, Poland.
Mark IlgenDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan.
Amy BohnertDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan.
Kristen BarryDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan.
Rafał PłoskiDepartment of Medical Genetics, Medical University of Warsaw, Warsaw, Poland.
Frederic C BlowDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan.
Marcin WojnarDepartment of Psychiatry, Medical University of Warsaw, Warsaw, Poland.
Medical University of Warsaw · PLDepartment of Veterans Affairs · AUInstitute of Cardiology · PLUniversity of Michigan–Ann Arbor · USMedical University of Lodz · PL

Funding

International Collaborative Alcohol & Injury Research Training Program in PolandD43TW007569 · FIC · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BLOW, FREDERIC C · 2006 to 2010
$723k
FIC NIH HHS 5 D43 TW007569FIC NIH HHS D43 TW007569
6 · The paper itself

Abstract

objectiveDisrupted-in-schizophrenia 1 (DISC1) has been linked to vulnerability to a variety of psychiatric disorders and neuropsychiatric phenotypes. However, DISC1 has not been frequently examined as a potential risk factor for substance dependence. An association between opioid dependence and DISC1 rs2738888 polymorphism has been recently reported. In addition, opioid dependence was associated with rs6419156 located close to the protein phosphatase 3 catalytic subunit alpha isoform (PPP3CA) gene. The aim of the present study was to examine the associations between opioid dependence with rs2738888 and rs6419156 in an independent sample.

methodThe selected polymorphisms were genotyped in a sample of 392 individuals (69.9% male) diagnosed as alcohol- and/or opioid-dependent. A control group (n = 257; 67.7% male) was derived from the Polish National Health Survey (N = 14,350).

resultsThe frequency of rs2738888 C allele was higher in controls than in opioid-dependent cases (OR = 0.65, p = .045). Phenotypic-oriented analyses performed within opioid-dependent individuals revealed the association between lifetime suicide attempt and rs2738888. The C allele of rs2738888 had a protective effect on lifetime suicide attempt in opioid-dependent patients (OR = 0.25, p = .003). Rs6419156 was not associated with substance dependence in the examined sample.

conclusionsThe DISC1 may play an important role in vulnerability to opioid dependence. In addition, DISC1 may also be a genetic risk factor for suicide attempt in opioid-dependent individuals.

Indexed as

AdultAgedCase-Control StudiesCohort StudiesFemaleGene FrequencyGenotypeHumansMaleMiddle AgedNerve Tissue ProteinsOpioid-Related DisordersPhenotypePolandPolymorphism, Single NucleotideRisk FactorsDISC1 protein, humanNerve Tissue Proteins

Identifiers

PMID26997180
PMCPMC4803654
OpenAlexW2303611434

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.