Evidence map›Paper›PMID 26996313›Full record

ArticleEpidemiology and infection2016

Whole genome sequencing provides insights into the genetic determinants of invasiveness in Salmonella Dublin.

M Mohammed, M Cormican

Open access · bronzeAbstract read
In one paragraph

Article in Epidemiology and infection, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 29 citations in OpenAlex.

  1. Cross-species genomic analysis ofOne health (Amsterdam, Netherlands) · 2026
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  2. Microbiology spectrum · 2026
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  4. Intracranial infection and sepsis in infants caused byWorld journal of clinical cases · 2023
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  5. Article
  6. Clonal relation betweenFrontiers in veterinary science · 2023
    Article
  7. Article
  8. Article
  9. Whole-Genome Investigation ofMicroorganisms · 2022
    Article
  10. Article
  11. Article
  12. Genetic Markers inMicroorganisms · 2020
    Article
  13. Epidemiology ofApplied and environmental microbiology · 2020
    Article
  14. Article
  15. Observational
  16. Article
  17. Article
  18. Article
  19. Disentangling a complex nationwideEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

M MohammedFaculty of Science and Technology,Anglia Ruskin University,Cambridge,UK.
M CormicanSchool of Medicine,National University of Ireland Galway,Galway,Ireland.
Ollscoil na Gaillimhe – University of Galway · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Salmonella enterica subsp. enterica serovar Dublin (S. Dublin) is one of the non-typhoidal Salmonella (NTS); however, a relatively high proportion of human infections are associated with invasive disease. We applied whole genome sequencing to representative invasive and non-invasive clinical isolates of S. Dublin to determine the genomic variations among them and to investigate the underlying genetic determinants associated with invasiveness in S. Dublin. Although no particular genomic variation was found to differentiate in invasive and non-invasive isolates four virulence factors were detected within the genome of all isolates including two different type VI secretion systems (T6SS) encoded on two Salmonella pathogenicity islands (SPI), including SPI-6 (T6SSSPI-6) and SPI-19 (T6SSSPI-19), an intact lambdoid prophage (Gifsy-2-like prophage) that contributes significantly to the virulence and pathogenesis of Salmonella serotypes in addition to a virulence plasmid. These four virulence factors may all contribute to the potential of S. Dublin to cause invasive disease in humans.

Indexed as

Genome, BacterialGenomic IslandsHumansIrelandPhylogenySalmonella entericaSalmonella InfectionsSequence Analysis, DNAVirulenceVirulence FactorsVirulence FactorsComparative genomicsinvasivenessSalmonella Dublin

Identifiers

PMID26996313
PMCPMC9150539
OpenAlexW2308666743

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.