Evidence map›Paper›PMID 26996133›Full record

ReviewExperimental neurology2017

Models of axon regeneration in Drosophila.

E J Brace, Aaron DiAntonio

Abstract readReview
In one paragraph

Review in Experimental neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Glial regenerative response in the imaginal discs ofNeural regeneration research · 2023
    Article
  8. Frontiers in neuroscience · 2023
    Review
  9. Axon Regeneration: A Subcellular Extension in Multiple Dimensions.Cold Spring Harbor perspectives in biology · 2022
    Review
  10. Current neuropharmacology · 2022
    Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Dendrite regeneration of adultGenes & development · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

E J BraceDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA, 63110.
Aaron DiAntonioDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA, 63110. Electronic address: diantonio@wustl.edu.

Funding

Regulation of axonal degeneration by the DLK kinaseR37NS065053 · NINDS · WASHINGTON UNIVERSITY · PI Aaron Diantonio · 2020 to 2026
$4.3M
MOLECULAR PATHWAYS REGULATING SYNAPTIC GROWTHR01DA020812 · NIDA · WASHINGTON UNIVERSITY · PI DIANTONIO, AARON · 2007 to 2016
$3.3M
REGULATION OF AXONAL DEGENERATION BY THE DLK KINASER01NS065053 · NINDS · WASHINGTON UNIVERSITY · PI DIANTONIO, AARON · 2010 to 2019
$3.3M
NIDA NIH HHS R01 DA020812NINDS NIH HHS R01 NS065053NINDS NIH HHS R37 NS065053
6 · The paper itself

Abstract

Maintaining neuronal connectivity in the face of injury and disease is a major challenge for the nervous system. The great length of axons makes them particularly vulnerable to insult with dire consequences for neuronal function. In the peripheral nervous system there is a program of axonal regeneration that can reestablish connectivity. In the mammalian central nervous system, however, injured axons have little or no capacity to regenerate. The molecular mechanisms that promote axon regeneration have begun to be identified and many of the implicated pathways are evolutionarily conserved. Here we discuss Drosophila models of axonal regrowth, describe insights derived from these studies, and highlight future directions in the use of the fly for dissecting the mechanisms of axonal regeneration.

Indexed as

Disease Models, AnimalAnimalsAnimals, Genetically ModifiedAxonsDrosophilaDrosophila ProteinsMutationNerve DegenerationNerve RegenerationDrosophila ProteinsAxon injuryAxon regenerationDegenerationDendriteDLKDrosophilaJNKWallenda

Identifiers

PMID26996133
PMCPMC5026866

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.