ArticleThe Journal of pediatrics2016
Birth Size, Early Life Weight Gain, and Midchildhood Cardiometabolic Health.
Article in The Journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05124847 (Time Restricted Eating as a Treatment for Pediatric Obesity), which is not on this map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Time Restricted Eating as a Treatment for Pediatric Obesity
Who cites it
47 citing papers in PubMed, 83 citations in OpenAlex.
- Association of cow's milk intake in early childhood with adiposity and cardiometabolic risk in early adolescence.The American journal of clinical nutrition · 2022Trial
- Protocol for the infant growth and development (iGrowUp) study: the role of food and non-food self-regulation in children's obesity-related risk.BMC public health · 2025Article
- Neonatal malnutrition, body composition, and childhood obesity in critically ill infants.Maternal health, neonatology and perinatology · 2025Article
- The human placenta and its role in reproductive outcomes revisited.Physiological reviews · 2025Review
- Macrosomia and Childhood Growth Trajectories From Birth to 10 Years of Age: Findings From the ROLO Longitudinal Birth Cohort Study.Journal of obesity · 2025Article
- Evaluation of the Prime Diet Quality Score from Early Childhood Through Mid-Adolescence.The Journal of nutrition · 2024Article
- Veillonella and Bacteroides are associated with gestational diabetes mellitus exposure and gut microbiota immaturity.PloS one · 2024Article
- The impact of macrosomia on cardiometabolic health in preteens: findings from the ROLO longitudinal birth cohort study.Nutrition & metabolism · 2023Article
- Developmental Contributions to Obesity: Nutritional Exposures in the First Thousand Days.Gastroenterology clinics of North America · 2023Review
- Age-dependent associations of human milk oligosaccharides with body size and composition up to 4 years of age.The American journal of clinical nutrition · 2023Article
- Multigenerational birth cohort study in China: importance, necessity and beyond.World journal of pediatrics : WJP · 2023Article
- Prevalence of early childhood obesity in Ireland: Differences over time, between sexes and across child growth criteria.Pediatric obesity · 2022Article
- History of infertility and pregnancy outcomes in Project Viva: a prospective study.BMC pregnancy and childbirth · 2022Article
- Menstrual cycle length and adverse pregnancy outcomes among women in Project Viva.Paediatric and perinatal epidemiology · 2022Article
- Prenatal exposure to ambient air pollution and traffic and indicators of adiposity in early childhood: the Healthy Start study.International journal of obesity (2005) · 2022Article
- Maternal Midpregnancy Leptin and Adiponectin Levels as Predictors of Autism Spectrum Disorders: A Prenatal Cohort Study.The Journal of clinical endocrinology and metabolism · 2021Article
- Metabolic Consequences of Gestational Cannabinoid Exposure.International journal of molecular sciences · 2021Review
- In Utero Exposure to Δ9-Tetrahydrocannabinol Leads to Postnatal Catch-Up Growth and Dysmetabolism in the Adult Rat Liver.International journal of molecular sciences · 2021Article
- Separating Algorithms From Questions and Causal Inference With Unmeasured Exposures: An Application to Birth Cohort Studies of Early Body Mass Index Rebound.American journal of epidemiology · 2021Article
- Developmental origins of metabolic diseases.Physiological reviews · 2021Review
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
Abstract
objectiveTo examine associations of birth size and weight gain during 4 early-life age intervals with midchildhood adiposity and metabolic profile and to evaluate for an interaction between birth size and early-life weight gain. STUDY
designUsing data from 963 participants of Project Viva, a US prebirth cohort, we used multivariable linear regression to examine relations of birth size (tertiles of birthweight-for-gestational-age z-score) and weight gain (body mass index z-score [BMIZ] change) during 4 age intervals (birth-6 months, 6 months-1 year, 1-2 years, 2-3 years) with body composition and metabolic biomarkers during midchildhood (6.6-10.7 years).
resultsAfter accounting for confounders and previous growth, greater BMIZ change during all 4 age intervals corresponded with higher midchildhood adiposity, with larger effect sizes for later (1-2 years and 2-3 years) vs earlier (birth-6 months and 6 months-1 year) time frames. We observed effect modification by birth size for the birth-6 months and 6 months-1 year intervals. Greater birth-6 months BMIZ change was associated with higher overall adiposity (0.40 [95% CI 0.29, 0.51] kg dual x-ray absorptiometry total fat mass per z-score) among children in the highest birth size tertile. Similar associations were observed for central adiposity. Each increment in 6 months-1 year BMIZ change corresponded with 0.55 (0.05, 1.05) units higher homeostatic model assessment of insulin resistance and 2.68 (0.96, 4.40) ng/mL higher leptin among the smallest infants.
conclusionsBMIZ gain after 1 year is associated with greater midchildhood adiposity regardless of birth size, whereas the long-term influence of weight gain during the first postnatal year may depend on size at birth. Future studies are warranted to validate findings and examine relations with conventional birth size cut-offs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.