Evidence map›Paper›PMID 26995546›Full record

ReviewCurrent protocols in pharmacology2016

Overview of Transgenic Glioblastoma and Oligoastrocytoma CNS Models and Their Utility in Drug Discovery.

Fuyi Chen, Albert Becker, Joseph LoTurco

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current protocols in pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Frontiers in oncology · 2021
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Fuyi ChenDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, Conn.
Albert BeckerDepartment of Neuropathology, University of Bonn Medical Center, Bonn, Germany.
Joseph LoTurcoDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, Conn.

Funding

SYNAPTIC PHYSIOLOGY OF NEOCORTICAL ECTOPIASP01HD020806 · NICHD · BETH ISRAEL DEACONESS MEDICAL CENTER · PI GALABURDA, ALBERT MARK · 1986 to 2009
$8.8M
PROJ 3: NEUROBEHAVIOR: BEHAVIOTAL CONSEQUENCES OF EMBRYONIC DISRUPTIONP01HD057853 · NICHD · BETH ISRAEL DEACONESS MEDICAL CENTER · PI GALABURDA, ALBERT MARK · 2009 to 2014
$5.3M
MOLECULAR REGULATION OF NEOCORTICAL NEUROGENESISR01MH056524 · NIMH · UNIVERSITY OF CONNECTICUT STORRS · PI LOTURCO, JOSEPH J · 2003 to 2012
$3.3M
DYSLEXIA SUSCEPTIBILITY GENES AND MECHANISMS OF NEURONAL DEVELOPMENTR01HD055655 · NICHD · UNIVERSITY OF CONNECTICUT STORRS · PI LOTURCO, JOSEPH J · 2008 to 2012
$1.6M
NICHD NIH HHS P01 HD020806NICHD NIH HHS P01 HD057853NICHD NIH HHS R01 HD055655NICHD NIH HHS R01HD055655NIMH NIH HHS R01 MH056524NIMH NIH HHS R01MH056524
6 · The paper itself

Abstract

Many animal models have been developed to investigate the sources of central nervous system (CNS) tumor heterogeneity. Reviewed in this unit is a recently developed CNS tumor model using the piggyBac transposon system delivered by in utero electroporation, in which sources of tumor heterogeneity can be conveniently studied. Their applications for studying CNS tumors and drug discovery are also reviewed. © 2016 by John Wiley & Sons, Inc.

Indexed as

Disease Models, AnimalAnimalsAnimals, Genetically ModifiedAstrocytomaCentral Nervous SystemDrug DiscoveryGlioblastomaRats, Wistaranaplastic oligoastrocytomaatypical teratoid rhabdoid tumorcentral nervous systemglioblastoma multiformein utero electroporationpiggyBac transposontumor heterogeneity

Identifiers

PMID26995546
PMCPMC5043528

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.