ArticleJournal of pediatric surgery2016
Initial diagnostic management of pediatric bone tumors.
Article in Journal of pediatric surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Diagnostic efficacy of pediatric image-guided core needle biopsy of musculoskeletal lesions.Skeletal radiology · 2026Article
- Fibular mid-shaft stress fractures in a 4-year-old child: A case report and literature review of the first decade of children with fibular stress fracture.SAGE open medical case reports · 2026Article
- Pediatric and Young Adult Image-Guided Percutaneous Bone Biopsy-A New Standard of Care?Annals of surgical oncology · 2023Article
- Diagnosis and staging of malignant bone tumours in children: what is due and what is new?Journal of children's orthopaedics · 2021Article
- Ewing Sarcoma-Diagnosis, Treatment, Clinical Challenges and Future Perspectives.Journal of clinical medicine · 2021Review
- Image-guided core needle biopsy for Ewing sarcoma of bone: a 10-year single-institution review.European radiology · 2020Article
- The current status of MRI in the pre-operative assessment of intramedullary conventional appendicular osteosarcoma.Skeletal radiology · 2019Review
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
backgroundOsteosarcoma (OS) and the Ewing sarcoma family of tumors (ESFT) are the most common primary pediatric bone malignancies. We sought to assess the diagnostic accuracy of initial tumor biopsies in patients with OS or ESFT at a pediatric cancer center.
methodsAll biopsies performed at initial presentation of patients with OS or ESFT at our institution from 2003 to 2012 were retrospectively reviewed. Diagnostic accuracy and incidence of complications were correlated with study variables using logistic regression analysis.
resultsOne hundred forty-two biopsies were performed in 105 patients (median age 13.4years, range: 1.8-23.0), 104 (73.2%) OS and 38 (27.8%) ESFT. Thirty-one (21.8%) were performed on metastatic sites. Eighty-five (76.6%) of 111 primary site biopsies were open procedures, and 26 were percutaneous (23.4%). Primary site biopsies were successful in 94.1% of open and 73.1% of percutaneous procedures. Odds of obtaining a successful diagnostic specimen were 7.8 times higher with open approach (CI: 1.6-36.8). Metastatic site biopsies were successful in 66.7% of percutaneous and 100% of open and thoracoscopic procedures.
conclusionBiopsy of metastatic sites was equal to primary site in obtaining diagnostic material with the added benefit of accurate staging, with few adverse events and high diagnostic yield.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.