ArticleJournal of cancer research and clinical oncology2016
Volume matters in the systemic treatment of metastatic pancreatic cancer: a population-based study in the Netherlands.
Article in Journal of cancer research and clinical oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 53 citations in OpenAlex.
- Temporal Trends in Pancreatic Cancer in New South Wales, Australia: A Longitudinal Population-Based Study of Incidence, Surgery and Survival.ANZ journal of surgery · 2026Article
- Simultaneous resection of pancreatic cancer and liver metastases following total neoadjuvant therapy: A case series and analysis of the National Cancer Database.Annals of hepato-biliary-pancreatic surgery · 2026Article
- Increased risk of multiple metastases and worse overall survival of metastatic pancreatic body and tail cancer: a retrospective cohort study.Gland surgery · 2024Article
- Limited Generalizability of Retrospective Single-Center Cohort Study in Comparison to Multicenter Cohort Study on Prognosis of Hepatocellular Carcinoma.Journal of hepatocellular carcinoma · 2024Article
- Real‑world treatment outcomes among patients with metastatic pancreatic cancer in Japan: The Tokushukai real‑world data project.Molecular and clinical oncology · 2023Article
- Hospital volume and prognosis of patients with metastatic pancreatic cancer: A study using the Osaka Cancer Registry.Journal of cancer research and clinical oncology · 2023Article
- Management of Patients With Pancreatic Cancer Using the "Right Track" Model.The oncologist · 2023Review
- Disparities in pancreatic cancer care and research in Native Americans: Righting a history of wrongs.Cancer · 2022Article
- Treatment Response and Conditional Survival in Advanced Pancreatic Cancer Patients Treated with FOLFIRINOX: A Multicenter Cohort Study.Journal of oncology · 2022Article
- Systematic review of the predictors of health service use in pancreatic cancer.American journal of cancer research · 2022Review
- The immune escape signature predicts the prognosis and immunotherapy sensitivity for pancreatic ductal adenocarcinoma.Frontiers in oncology · 2022Article
- Disparities in Stage-Specific Guideline-Concordant Cancer-Directed Treatment for Patients with Pancreatic Adenocarcinoma.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021Article
- Analysing the attributes of Comprehensive Cancer Centres and Cancer Centres across Europe to identify key hallmarks.Molecular oncology · 2021Article
- Disparities in access to health care system as determinant of survival for patients with pancreatic cancer in the State of São Paulo, Brazil.Scientific reports · 2021Article
- Pancreatic Enzyme Replacement Therapy in Patients Undergoing First-Line Gemcitabine PlusFrontiers in oncology · 2021Article
- Article
- Observational Study of Clinical Practice in Patients with Pancreatic Adenocarcinoma in Greece.Journal of oncology · 2020Article
- Adjuvant chemotherapy followed by concurrent chemoradiation is associated with improved survival for resected stage I-II pancreatic cancer.Cancer medicine · 2019Article
- Implementation of Novel Molecular Biomarkers for Non-small Cell Lung Cancer in the Netherlands: How to Deal With Increasing Complexity.Frontiers in oncology · 2019Review
- Dose escalation of radiation therapy with or without induction chemotherapy for unresectable locally advanced pancreatic cancer.Radiation oncology (London, England) · 2018Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIn pancreatic surgery, a relation between surgical volume and postoperative mortality and overall survival (OS) has been recognized, with high-volume centers reporting significantly better survival rates. We aimed to explore the influence of hospital volume on administration of palliative chemotherapy and OS in the Netherlands.
methodsPatients diagnosed between 2007 and 2011 with metastatic pancreatic cancer were identified in the Netherlands Cancer Registry. Three types of high-volume centers were defined: high-volume (1) incidence center, based on the number of patients diagnosed with metastatic pancreatic cancer, (2) treatment center based on number of patients with metastatic pancreatic cancer who started treatment with palliative chemotherapy and (3) surgical center based on the number of resections with curative intent for pancreatic cancer. Independent predictors of administration of palliative chemotherapy were evaluated by means of logistic regression analysis. The multivariable Cox proportional hazard model was used to assess the impact of being diagnosed or treated in high-volume centers on survival.
resultsA total of 5385 patients presented with metastatic pancreatic cancer of which 24 % received palliative chemotherapy. Being treated with chemotherapy in a high-volume chemotherapy treatment center was associated with improved survival (HR 0.76, 95 % CI 0.67-0.87). Also, in all patients with metastatic pancreatic cancer, being diagnosed in a high-volume surgical center was associated with improved survival (HR 0.74, 95 % CI 0.66-0.83).
conclusionsHospital volume of palliative chemotherapy for metastatic pancreatic cancer was associated with improved survival, demonstrating that a volume-outcome relationship, as described for pancreatic surgery, may also exist for pancreatic medical oncology.
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