Evidence map›Paper›PMID 26995220›Full record

ArticleVirus genes2016

Merkel cell polyomavirus in Merkel cell carcinogenesis: small T antigen-mediates c-Jun phosphorylation.

Julie H Wu, Rebecca A Simonette, Harrison P Nguyen, Peter L Rady, Stephen K Tyring

Abstract read
PubMed Publisher
In one paragraph

Article in Virus genes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Human DNA Virus Exploitation of the MAPK-ERK Cascade.International journal of molecular sciences · 2019
    Review
  7. Viral Oncology: Molecular Biology and Pathogenesis.Journal of clinical medicine · 2017
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Julie H WuDepartment of Dermatology, University of Texas Medical School at Houston, 6431 Fannin Street, Houston, TX, 77030, USA.
Rebecca A SimonetteDepartment of Dermatology, University of Texas Medical School at Houston, 6431 Fannin Street, Houston, TX, 77030, USA.
Harrison P NguyenDepartment of Dermatology, University of Texas Medical School at Houston, 6431 Fannin Street, Houston, TX, 77030, USA.
Peter L RadyDepartment of Dermatology, University of Texas Medical School at Houston, 6431 Fannin Street, Houston, TX, 77030, USA.
Stephen K TyringDepartment of Dermatology, University of Texas Medical School at Houston, 6431 Fannin Street, Houston, TX, 77030, USA. styring@ccstexas.com.
The University of Texas Health Science Center at Houston · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer associated with the Merkel cell polyomavirus (MCPyV). The MCPyV genome, which is clonally integrated in the majority of MCCs, encodes the regulatory small T (sT) antigen. Previously, reports have established MCPyV sT antigen as a potent oncogene capable of inducing cell transformation. In the current study, we demonstrate a distinct role for c-Jun hyperactivation in MCPyV sT antigen pathogenesis. As MCPyV sT antigen's association with aggressive cancer growth has been previously established, this finding may represent a potential therapeutic target for the treatment of MCCs.

Indexed as

Antigens, Viral, TumorCarcinoma, Merkel CellCell Transformation, NeoplasticGene Expression ProfilingGene Expression Regulation, ViralHEK293 CellsHumansMerkel cell polyomavirusPhosphorylationPolyomavirus InfectionsProto-Oncogene Proteins c-junSkin NeoplasmsTumor Virus InfectionsAntigens, Viral, TumorProto-Oncogene Proteins c-junc-JunERKMEKMerkel cell carcinomaMerkel cell polyomavirus (MCPyV)Small T antigen

Identifiers

PMID26995220
OpenAlexW2296904082

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.