Evidence map›Paper›PMID 26995206›Full record

ArticleEuropean radiology2016

Contrast volume reduction using third generation dual source computed tomography for the evaluation of patients prior to transcatheter aortic valve implantation.

Daniel O Bittner, Martin Arnold, Lutz Klinghammer, Annika Schuhbaeck, Michaela M Hell, Gerd Muschiol, Soeren Gauss, Michael Lell, Michael Uder, Udo Hoffmann and 2 more

Abstract read
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Article in European radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Trial
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  7. Review
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  12. Article
  13. Biomechanics of Transcatheter Aortic Valve Implant.Bioengineering (Basel, Switzerland) · 2022
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Noninvasive aortic imaging.Cardiovascular diagnosis and therapy · 2018
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Daniel O BittnerFriedrich-Alexander University Erlangen-Nürnberg (FAU), Department of Internal Medicine 2 (Cardiology), University Hospital Erlangen, Ulmenweg 18, D-91054, Erlangen, Germany. daniel.bittner@uk-erlangen.de.
Martin ArnoldFriedrich-Alexander University Erlangen-Nürnberg (FAU), Department of Internal Medicine 2 (Cardiology), University Hospital Erlangen, Ulmenweg 18, D-91054, Erlangen, Germany.
Lutz KlinghammerFriedrich-Alexander University Erlangen-Nürnberg (FAU), Department of Internal Medicine 2 (Cardiology), University Hospital Erlangen, Ulmenweg 18, D-91054, Erlangen, Germany.
Annika SchuhbaeckFriedrich-Alexander University Erlangen-Nürnberg (FAU), Department of Internal Medicine 2 (Cardiology), University Hospital Erlangen, Ulmenweg 18, D-91054, Erlangen, Germany.
Michaela M HellFriedrich-Alexander University Erlangen-Nürnberg (FAU), Department of Internal Medicine 2 (Cardiology), University Hospital Erlangen, Ulmenweg 18, D-91054, Erlangen, Germany.
Gerd MuschiolFriedrich-Alexander University Erlangen-Nürnberg (FAU), Department of Internal Medicine 2 (Cardiology), University Hospital Erlangen, Ulmenweg 18, D-91054, Erlangen, Germany.
Soeren GaussFriedrich-Alexander University Erlangen-Nürnberg (FAU), Department of Internal Medicine 2 (Cardiology), University Hospital Erlangen, Ulmenweg 18, D-91054, Erlangen, Germany.
Michael LellFriedrich-Alexander University Erlangen-Nürnberg (FAU), Department of Radiology, University Hospital Erlangen, Erlangen, Germany.
Michael UderFriedrich-Alexander University Erlangen-Nürnberg (FAU), Department of Radiology, University Hospital Erlangen, Erlangen, Germany.
Udo HoffmannCardiac MR PET CT Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Stephan AchenbachFriedrich-Alexander University Erlangen-Nürnberg (FAU), Department of Internal Medicine 2 (Cardiology), University Hospital Erlangen, Ulmenweg 18, D-91054, Erlangen, Germany.
Mohamed MarwanFriedrich-Alexander University Erlangen-Nürnberg (FAU), Department of Internal Medicine 2 (Cardiology), University Hospital Erlangen, Ulmenweg 18, D-91054, Erlangen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesChronic renal failure is common in patients referred for transcatheter aortic valve implantation (TAVI). CT angiography is recommended and provides crucial information prior to TAVI. We evaluated the feasibility of a reduced contrast volume protocol for pre-procedural CT imaging.

methodsForty consecutive patients were examined with prospectively ECG-triggered high-pitch spiral acquisition using a novel third-generation dual-source CT system; 38 ml contrast agent was used. Image quality was graded on a visual scale (1-4). Contrast attenuation was measured at the level of the aortic root and at the iliac bifurcation.

resultsMean patient age was 82 ± 6 years (23 males; 58 %). Mean attenuation/average image quality was 285 ± 60 HU/1.5 at the aortic annulus compared to 289 ± 74 HU/1.8 at the iliac bifurcation (p = 0.77/p = 0.29). Mean estimated effective radiation dose was 2.9 ± 0.3 mSv. A repeat acquisition was necessary in one patient due to image quality. Out of the 35 patients who underwent TAVI, 31 (89 %) patients had no or mild aortic regurgitation. Thirty-two (91 %) patients were discharged successfully.

conclusionPre-procedural CTA with a total of 38 ml contrast volume is feasible and clinically useful, using third-generation dual-source CT, allowing comprehensive imaging for procedural success. KEY POINTS: • Reduction of contrast agent volume is crucial in patients with chronic renal failure. • Novel third-generation computed tomography helps to reduce contrast agent volume. • Pre-procedural CT allows comprehensive imaging for procedural success before heart valve implantation. • A low-contrast CT protocol is feasible for pre-procedural TAVI planning.

Indexed as

AgedAged, 80 and overAortic ValveAortic Valve InsufficiencyAortic Valve StenosisComputed Tomography AngiographyContrast MediaFeasibility StudiesFemaleHumansKidney Failure, ChronicMalePreoperative CareProspective StudiesTomography, X-Ray ComputedTranscatheter Aortic Valve ReplacementContrast MediaAortographyComputed tomographyHeart valve prosthesis implantationLow contrast agentTranscatheter aortic valve implantation (TAVI)

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.