Evidence map›Paper›PMID 26994715›Full record

SynthesisThe British journal of surgery2016

Meta-analysis of negative-pressure wound therapy for closed surgical incisions.

N Hyldig, H Birke-Sorensen, M Kruse, C Vinter, J S Joergensen, J A Sorensen, O Mogensen, R F Lamont, C Bille

7 registry-linked trialsOpen access · hybridAbstract readMeta-AnalysisSystematic ReviewVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The British journal of surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 7 registered trials, which are not on this map. Cited by 93 papers, 26 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 26 pooled it
25.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03395613 naunknown statusnot on this mapstarted 2018, after this paper: background citation

Prophylactic Use of a Negative Pressure Incision Management System in Infrainguinal Vascular Surgery - A Multicentre Randomized Controlled Trial

TypeinterventionalSponsorKarolinska University HospitalRan2018 to 2023Enrolled118ConditionsPostoperative Surgical Site InfectionArmsNPWT
NCT03773575 nacompletednot on this mapstarted 2019, after this paper: background citation

Evaluation of Closed Incision Negative Pressure Dressing (PREVENA) to Prevent Lower Extremity Amputation Wound Complications

TypeinterventionalSponsorThomas Jefferson UniversityRan2019 to 2024Enrolled272ConditionsAmputation, Amputation, Postoperative, Sequelae, Wound DehiscenceArmsPREVENA™ PEEL & PLACE™ Dressing Kit
NCT04985552 nanot yet recruitingnot on this mapstarted 2021, after this paper: background citation

Closed Incision Negative Pressure Therapy Compared to Conventional Dressing Following Autologous Abdominal Tissue Breast Reconstruction: A Pilot Randomized Control Trial

TypeinterventionalSponsorMcMaster UniversityRan2021 to 2022Enrolled24ConditionsBreast CancerArmsDIEP Breast Reconstruction, ciNPT, Conventional Tape Dressings
NCT05266053 nacompletednot on this mapstarted 2022, after this paper: background citation

Negative Pressure Wound Therapy-PICO: Cosmesis in Repeat C-Sections

TypeinterventionalSponsorIndiana UniversityRan2022 to 2023Enrolled24ConditionsHypertrophic Skin Condition of Anterior AbdomenArmsPICO 7 dressing, Standard wound dressing
NCT05474911 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Randomized comparative clinical study between two treatment strategies in patients with pilonidal sinus: conventional care versus negative pressure therapy.

TypeinterventionalSponsorSebastiano BiondoRan2022 to 2023Enrolled94ConditionsPilonidal Sinus, Wound HealArmsNegative pressure therapy, Conventional wound care
NCT05907941 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Closed Incision Negative Pressure Therapy Compared to Conventional Dressing Following Autologous Abdominal Tissue Breast Reconstruction: A Randomized Control Trial

TypeinterventionalSponsorMcMaster UniversityRan2024 to 2026Enrolled114ConditionsBreast Cancer, Wound Dehiscence, SurgicalArmsciNPT, Conventional Tape Dressings, DIEP Breast Reconstruction
NCT06493539 phase1withdrawnnot on this mapstarted 2024, after this paper: background citation

A Novel Application of Closed Incision Negative Pressure Wound Therapy for the Post-Surgical Management of Lower Extremity Amputations: A Randomized Clinical Pilot Study

TypeinterventionalSponsorUniversity of Southern CaliforniaRan2024 to 2025Enrolled0ConditionsWound Heal, Wound DehiscenceArmsStandard of Care group, CINPWT
3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 26 syntheses or guidelines pooled it, 231 citations in OpenAlex.

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  8. Can prophylactic negative pressure wound therapy improve clinical outcomes in spinal fusion surgery? A meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2022
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33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

N HyldigDepartment of Plastic Surgery, Odense University Hospital, University of Southern Denmark, Institute of Clinical Research, Research Unit of Plastic Surgery, Odense, Denmark.
H Birke-SorensenInstitute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.
M KruseCentre for Health Economics Research (COHERE), University of Southern Denmark, Odense, Denmark.
C VinterDepartment of Gynaecology and Obstetrics, Odense University Hospital, University of Southern Denmark, Institute of Clinical Research, Research Unit of Gynaecology and Obstetrics, Odense, Denmark.
J S JoergensenDepartment of Gynaecology and Obstetrics, Odense University Hospital, University of Southern Denmark, Institute of Clinical Research, Research Unit of Gynaecology and Obstetrics, Odense, Denmark.
J A SorensenDepartment of Plastic Surgery, Odense University Hospital, University of Southern Denmark, Institute of Clinical Research, Research Unit of Plastic Surgery, Odense, Denmark.
O MogensenDepartment of Gynaecology and Obstetrics, Odense University Hospital, University of Southern Denmark, Institute of Clinical Research, Research Unit of Gynaecology and Obstetrics, Odense, Denmark.
R F LamontDepartment of Gynaecology and Obstetrics, Odense University Hospital, University of Southern Denmark, Institute of Clinical Research, Research Unit of Gynaecology and Obstetrics, Odense, Denmark.
C BilleDepartment of Plastic Surgery, Odense University Hospital, University of Southern Denmark, Institute of Clinical Research, Research Unit of Plastic Surgery, Odense, Denmark.
University of Southern Denmark · DKOdense University Hospital · DKAarhus University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative wound complications are common following surgical procedures. Negative-pressure wound therapy (NPWT) is well recognized for the management of open wounds and has been applied recently to closed surgical incisions. The evidence base to support this intervention is limited. The aim of this study was to assess whether NPWT reduces postoperative wound complications when applied to closed surgical incisions.

methodsThis was a systematic review and meta-analysis of randomized clinical trials of NPWT compared with standard postoperative dressings on closed surgical incisions.

resultsTen studies met the inclusion criteria, reporting on 1311 incisions in 1089 patients. NPWT was associated with a significant reduction in wound infection (relative risk (RR) 0·54, 95 per cent c.i. 0·33 to 0·89) and seroma formation (RR 0·48, 0·27 to 0·84) compared with standard care. The reduction in wound dehiscence was not significant. The numbers needed to treat were three (seroma), 17 (dehiscence) and 25 (infection). Methodological heterogeneity across studies led to downgrading of the quality of evidence to moderate for infection and seroma, and low for dehiscence.

conclusionCompared with standard postoperative dressings, NPWT significantly reduced the rate of wound infection and seroma when applied to closed surgical wounds. Heterogeneity between the included studies means that no general recommendations can be made yet.

Indexed as

Negative-Pressure Wound TherapyHumansModels, StatisticalPostoperative ComplicationsSeromaSurgical Wound DehiscenceSurgical Wound InfectionTreatment Outcome

Identifiers

PMID26994715
PMCPMC5069647
OpenAlexW2300002271

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

and 1 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.